JRNLclub, the online journal club

View Original

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.

Cell Metab. 2019 Dec 3;30(6):1055-1074.e8.

Pucino V1, Certo M1, Bulusu V2, Cucchi D3, Goldmann K3, Pontarini E3, Haas R3, Smith J3, Headland SE3, Blighe K3, Ruscica M4, Humby F3, Lewis MJ3, Kamphorst JJ2, Bombardieri M3, Pitzalis C3, Mauro C5.

  1. Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  2. Cancer Research UK Beatson Institute, Glasgow, UK; Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
  3. William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  4. Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
  5. Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Institute of Cardiovascular Sciences, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK; Institute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK. Electronic address: c.mauro@bham.ac.uk.

Presented by Valentina Pucino