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NLRP3 inflammasome activation drives tau pathology.

Nature. 2019 Nov;575(7784):669-673.

Ising C1,2 , Venegas C1, Zhang S1,2, Scheiblich H1,2, Schmidt SV3, Vieira-Saecker A1,2, Schwartz S1,2, Albasset S1,2, McManus RM1,2, Tejera D2, Griep A2, Santarelli F2, Brosseron F2, Opitz S1,2, Stunden J4, Merten M1, Kayed R5, Golenbock DT6, Blum D7, Latz E2,3,6, Buée L7, Heneka MT8,9,10.

  1. Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bonn, Germany.
  2. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  3. Institute of Innate Immunity, University Hospital Bonn, Bonn, Germany.
  4. IFM Therapeutics GmbH, Bonn, Germany.
  5. Mitchell Center for Neurodegenerative Diseases and Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
  6. Divison of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA.
  7. University of Lille, Inserm, CHU-Lille, UMR-S 1172, "Alzheimer & Tauopathies", Labex DISTALZ, Lille, France.
  8. Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital of Bonn, Bonn, Germany. michael.heneka@ukbonn.de.
  9. German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. michael.heneka@ukbonn.de.
  10. Divison of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA. michael.heneka@ukbonn.de.

Presented by Christina Ising