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Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Nat Genet. 2020 Apr;52(4):408-417.

Lin KH1, Rutter JC1, Xie A1, Pardieu B2, Winn ET3, Bello RD2,4, Forget A2, Itzykson R2,5, Ahn YR1, Dai Z1, Sobhan RT1, Anderson GR1, Singleton KR1, Decker AE1, Winter PS1, Locasale JW1, Crawford L6, Puissant A7, Wood KC8.

  1. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.
  2. Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.
  3. Division of Applied Mathematics, Brown University, Providence, RI, USA.
  4. Department of Hematology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  5. Service Hématologie Adultes, AP-HP, Hôpital Saint-Louis, Paris, France.
  6. Department of Biostatistics, Brown University, Providence, RI, USA.
  7. Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France. alexandre.puissant@inserm.fr.
  8. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu.

Presented by Justine C. Rutter