Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Nat Genet. 2020 Apr;52(4):408-417.

Lin KH¹, Rutter JC¹, Xie A¹, Pardieu B², Winn ET³, Bello RD^2,4, Forget A², Itzykson R^2,5, Ahn YR¹, Dai Z¹, Sobhan RT¹, Anderson GR¹, Singleton KR¹, Decker AE¹, Winter PS¹, Locasale JW¹, Crawford L⁶, Puissant A⁷, Wood KC⁸.

1. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA.
2. Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France.
3. Division of Applied Mathematics, Brown University, Providence, RI, USA.
4. Department of Hematology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
5. Service Hématologie Adultes, AP-HP, Hôpital Saint-Louis, Paris, France.
6. Department of Biostatistics, Brown University, Providence, RI, USA.
7. Université de Paris, Génomes, Biologie Cellulaire et Thérapeutique U944, INSERM, CNRS, Paris, France. alexandre.puissant@inserm.fr.
8. Department of Pharmacology and Cancer Biology, Duke University, Durham, NC, USA. kris.wood@duke.edu.

Presented by Justine C. Rutter