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Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Cell Metab. 2019 Sep 3;30(3):447-461.e5. doi: 10.1016/j.cmet.2019.07.004. | PubMed

Nicholas DA1, Proctor EA2, Agrawal M3, Belkina AC4, Van Nostrand SC2, Panneerseelan-Bharath L1, Jones AR 4th 1, Raval F1, Ip BC1, Zhu M1, Cacicedo JM5, Habib C1, Sainz-Rueda N5, Persky L1, Sullivan PG6, Corkey BE5, Apovian CM5, Kern PA7, Lauffenburger DA8, Nikolajczyk BS9.

  1. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA.
  2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
  3. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
  4. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA.
  5. Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
  6. Department of Neuroscience, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA.
  7. Department of Medicine, University of Kentucky, Lexington, KY 40536, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA.
  8. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: lauffen@mit.edu.
  9. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address: barb.nik@uky.edu.

Presented by Dequina Nicholas