Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Cell Metab. 2019 Sep 3;30(3):447-461.e5. doi: 10.1016/j.cmet.2019.07.004. | PubMed

Nicholas DA¹, Proctor EA², Agrawal M³, Belkina AC⁴, Van Nostrand SC², Panneerseelan-Bharath L¹, Jones AR 4th ¹, Raval F¹, Ip BC¹, Zhu M¹, Cacicedo JM⁵, Habib C¹, Sainz-Rueda N⁵, Persky L¹, Sullivan PG⁶, Corkey BE⁵, Apovian CM⁵, Kern PA⁷, Lauffenburger DA⁸, Nikolajczyk BS⁹.

1. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA.
2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
3. Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA.
4. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA.
5. Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.
6. Department of Neuroscience, Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA.
7. Department of Medicine, University of Kentucky, Lexington, KY 40536, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA.
8. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address: lauffen@mit.edu.
9. Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address: barb.nik@uky.edu.

Presented by Dequina Nicholas