Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

Nat Med. 2022 May;28(5):946-957. doi: 10.1038/s41591-022-01786-3.

Smita S Chandran, Jiaqi Ma, Martin G Klatt ... David A Scheinberg, Brian M Baker, Christopher A Klebanoff

Cancer Biology, Immunology & Microbiology, MedicineNicholas LiaoNovember 3, 20222022-05 (May)

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

Nat Med. 2022 Apr;28(4):752-765. doi: 10.1038/s41591-022-01749-8.

Cátia Monteiro, Lauritz Miarka, María Perea-García ... Neta Erez, RENACER, Manuel Valiente

Cancer Biology, MedicineNicholas LiaoOctober 4, 20222022-04 (Apr)

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection

Nat Biotechnol. 2021 Aug;39(8):928-935. doi: 10.1038/s41587-021-00878-8.

Susanna K Elledge, Xin X Zhou, James R Byrnes ... Kevin K Leung, Bryan Greenhouse, James A Wells

Biotechnology, Medicine, Immunology & MicrobiologyNicholas LiaoSeptember 15, 20222021-08 (Aug)

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism

Sci Transl Med. 2021 May 19;13(594):eaaw1564. doi: 10.1126/scitranslmed.aaw1564.

Joanne Ng, Serena Barral, Carmen De La Fuente Barrigon ... Maximilien Bencze, Simon N Waddington, Manju A Kurian

Biotechnology, Medicine, NeuroscienceNicholas LiaoAugust 9, 20222021-05 (May)

Morphine acts on spinal dynorphin neurons to cause itch through disinhibition

Sci Transl Med. 2021 Feb 3;13(579):eabc3774. doi: 10.1126/scitranslmed.abc3774.

Eileen Nguyen, Grace Lim, Huiping Ding, Junichi Hachisuka, Mei-Chuan Ko, Sarah E Ross

Medicine, NeuroscienceNicholas LiaoJune 14, 20222021-02 (Feb)

Curated variation benchmarks for challenging medically relevant autosomal genes

Nat Biotechnol. 2022 Feb 7. doi: 10.1038/s41587-021-01158-1.

Justin Wagner, Nathan D Olson, Lindsay Harris ... Chen-Shan Chin, Justin M Zook, Fritz J Sedlazeck

Biotechnology, Genetics & Genome Biology, MedicineNicholas LiaoApril 28, 20222022-02 (Feb)

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Nat Med. 2021 Oct;27(10):1752-1760. doi: 10.1038/s41591-021-01499-z.

Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis ... Periklis Panagopoulos, George N Dalekos, Evangelos J Giamarellos-Bourboulis

COVID-19, MedicineNicholas LiaoMarch 15, 20222021-10 (Oct)

Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: The polyG diseases

Neuron. 2021 Jun 2;109(11):1825-1835.e5. doi: 10.1016/j.neuron.2021.03.038.

Manon Boivin, Jianwen Deng, Véronique Pfister ... Jun Sone, Zhaoxia Wang, Nicolas Charlet-Berguerand

Medicine, Neuroscience, Genetics & Genome BiologyNicholas LiaoMarch 1, 20222021-06 (Jun)

Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA

Nat Commun. 2021 Oct 1;12(1):5753. doi: 10.1038/s41467-021-25576-6.

Aravind Natarajan, Alvin Han, Soumaya Zlitni ... Benjamin A Pinsky, Alexandria Boehm, Ami S Bhatt

COVID-19, MedicineNicholas LiaoFebruary 17, 20222021-10 (Oct)

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

Neuron. 2021 May 19;109(10):1675-1691.e9. doi: 10.1016/j.neuron.2021.03.026.

Evan Lester, Felicia K Ooi, Nadine Bakkar ... George A Carlson, Stanley B Prusiner, Roy Parker

Neuroscience, Biochemistry, MedicineNicholas LiaoFebruary 15, 20222021-05 (May)

Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Cell Metab. 2021 Aug 3;33(8):1685-1700.e9. doi: 10.1016/j.cmet.2021.06.005.

Anne Loft, Ana Jimena Alfaro, Søren Fisker Schmidt ... Mauricio Berriel Diaz, Blagoy Blagoev, Stephan Herzig

Metabolism, Biochemistry, MedicineNicholas LiaoFebruary 3, 20222021-08 (Aug)

Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity

Cell. 2021 Jul 22;184(15):4090-4104.e15. doi: 10.1016/j.cell.2021.05.013.

Drake Winslow Williams, Teresa Greenwell-Wild, Laurie Brenchley ... Maria Morasso, Muzlifah Haniffa, Niki Maria Moutsopoulos

Immunology & Microbiology, Genomics, MedicineNicholas LiaoJanuary 27, 20222021-07 (Jul)

Techniques for Collaborative Development of AI Models in the Age of COVID

Nat Med. 2021 Oct;27(10):1735-1743. doi: 10.1038/s41591-021-01506-3.

Ittai Dayan, Holger R Roth, Aoxiao Zhong ... Fiona J Gilbert, Mona G Flores, Quanzheng Li

Seminars, COVID-19, MedicineNicholas LiaoJanuary 20, 20222021-10 (Oct)

A condensate-hardening drug blocks RSV replication in vivo

Nature. 2021 Jul;595(7868):596-599. doi: 10.1038/s41586-021-03703-z.

Jennifer Risso-Ballester, Marie Galloux, Jingjing Cao ... Jean-François Eléouët, Marie-Anne Rameix-Welti, Ralf Altmeyer

Medicine, Cell & Developmental Bio, BiochemistryNicholas LiaoDecember 9, 20212021-07 (Jul)

HIV is associated with an increased risk of age-related clonal hematopoiesis among older adults

Nat Med. 2021 Jun;27(6):1006-1011. doi: 10.1038/s41591-021-01357-y.

Nila J Dharan, Paul Yeh, Mark Bloch ... Mark N Polizzotto, Mark A Dawson, ARCHIVE Study Group

Cancer Biology, MedicineNicholas LiaoOctober 19, 20212021-06 (Jun)

A myeloid-stromal niche and gp130 rescue in NOD2-driven Crohn's disease

Nature. 2021 May;593(7858):275-281. doi: 10.1038/s41586-021-03484-5.

Shikha Nayar, Joshua K Morrison, Mamta Giri ... Miriam Merad, Jaime Chu, Judy H Cho

Medicine, Immunology & MicrobiologyNicholas LiaoSeptember 16, 20212021-05 (May)

The distribution of cellular turnover in the human body

Nat Med. 2021 Jan;27(1):45-48. doi: 10.1038/s41591-020-01182-9.

Ron Sender, Ron Milo

Medicine, Cell & Developmental BioNicholas LiaoSeptember 14, 20212021-01 (Jan)

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child.

Nat Med. 2021 Jun 28. doi: 10.1038/s41591-021-01388-5.

Masato Ogishi, Rui Yang, Caner Aytekin ... Philippe Gros, Stéphanie Boisson-Dupuis, Jean-Laurent Casanova

Medicine, Immunology & MicrobiologyNicholas LiaoAugust 31, 20212021-06 (Jun)