Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes

Cell Rep. 2019 Dec 3;29(10):3009-3018.e4. doi: 10.1016/j.celrep.2019.11.007.

Hamidullah Khan, Ashish Anshu, Aman Prasad ... Wasakorn Kittipongdaja, David T Yang, Stefan M Schieke

Cancer BiologyNicholas LiaoOctober 22, 20202019-12 (Dec)

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

Cell Rep. 2019 Dec 10;29(11):3405-3420.e5. doi: 10.1016/j.celrep.2019.11.008.

William W Feng, Owen Wilkins, Scott Bang ... Chao Cheng, William B Kinlaw, Manabu Kurokawa

Cancer Biology, MetabolismNicholas LiaoSeptember 8, 20202019-12 (Dec)

Paroxysmal slow cortical activity in Alzheimer's disease and epilepsy is associated with blood-brain barrier dysfunction

Sci Transl Med. 2019 Dec 4;11(521):eaaw8954. doi: 10.1126/scitranslmed.aaw8954.

Dan Z Milikovsky, Jonathan Ofer, Vladimir V Senatorov Jr ... Felix Benninger, Daniela Kaufer, Alon Friedman

Neuroscience, MedicineNicholas LiaoAugust 17, 20202019-12 (Dec)

Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

Cell Rep. 2019 Dec 10;29(11):3652-3663.e5. doi: 10.1016/j.celrep.2019.11.014.

Todd Douglas, Maya Saleh

BiochemistryNicholas LiaoAugust 12, 20202019-12 (Dec)

Fungal aerobiota are not affected by time nor environment over a 13-y time series at the Mauna Loa Observatory

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25728-25733. doi: 10.1073/pnas.1907414116.

Laura Tipton, Geoffrey Zahn, Erin Datlof ... Patrick Sheridan, Anthony S Amend, Nicole A Hynson

MicrobiologyNicholas LiaoJuly 29, 20202019-12 (Dec)

Elite Control of HIV Is Associated With Distinct Functional and Transcriptional Signatures in Lymphoid Tissue CD8 + T Cells

Sci Transl Med. 2019 Dec 18;11(523):eaax4077. doi: 10.1126/scitranslmed.aax4077.

Son Nguyen, Claire Deleage, Samuel Darko ... Steven G Deeks, Marcus Buggert, Michael R Betts

Immunology & Microbiology, MedicineNicholas LiaoJuly 1, 20202019-12 (Dec)

Intermittent Rolling Is a Defect of the Extravasation Cascade Caused by Myosin1e-deficiency in Neutrophils

Proc Natl Acad Sci U S A. 2019 Dec 6;116(52):26752-26758. doi: 10.1073/pnas.1902502116.

Eduardo Vadillo, Sandra Chánez-Paredes, Hilda Vargas-Robles ... Daniel Alberto Girón-Pérez, Leopoldo Santos-Argumedo, Michael Schnoor

Cell & Developmental Bio, Immunology & MicrobiologyNicholas LiaoJune 25, 20202019-12 (Dec)

Programmable Inhibition and Detection of RNA Viruses Using Cas13

Mol Cell. 2019 Dec 5;76(5):826-837.e11.

Cameron Myhrvold, Catherine A Freije, Chloe K Boehm ... Nathan L Yozwiak, Feng Zhang, Pardis C Sabeti

Cell & Developmental Bio, Immunology & MicrobiologyNicholas LiaoJune 12, 20202019-12 (Dec)

Structures of Neisseria Meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States

Mol Cell. 2019 Dec 19;76(6):938-952.e5.

Wei Sun, Jing Yang, Zhi Cheng … Jizhong Lou, Erik J Sontheimer, Yanli Wang

Structural BiologyNicholas LiaoJune 5, 20202019-12 (Dec)

Comprehensive Analysis of a Mouse Model of Spontaneous Uveoretinitis Using Single-Cell RNA Sequencing

Proc Natl Acad Sci USA. 2019 Dec 16;116(52):26734-26744.

Jacob S Heng, Sean F Hackett, Genevieve L Stein-O'Brien, John Williams, Loyal A Goff, Jeremy Nathans

Immunology & MicrobiologyNicholas LiaoMay 28, 20202019-12 (Dec)

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.

Nat Med. 2019 Dec;25(12):1938-1947.

Khan S, Zhang X, Lv D, Konopleva M, Zheng G, Zhou D.

Cancer BiologyNicholas LiaoApril 25, 20202019-12 (Dec)

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.

Cell Metab. 2019 Dec 3;30(6):1055-1074.e8.

Pucino V, Certo M, Bulusu V, Bombardieri M, Pitzalis C, Mauro C.

Immunology & Microbiology, MetabolismNicholas LiaoApril 24, 20202019-12 (Dec)

QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25668-25676.

Qing R, Han Q, Skuhersky M, Chung H, Badr M, Schubert T, Zhang S.

Biochemistry, Structural BiologyDavid CantorMarch 27, 20202019-12 (Dec)

The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates

Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25068-25077.

Devaraj A, Buzzo JR, Mashburn-Warren L, Gloag ES, Novotny LA, Stoodley P, Bakaletz LO, Goodman SD.

Biochemistry, Immunology & MicrobiologyVictoria FangMarch 24, 20202019-12 (Dec)