T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.

Nat Immunol. 2020 Jan;21(1):65-74.

Jain A^1,2,3,4, Irizarry-Caro RA^1,2,3, McDaniel MM^1,2,3, Chawla AS^2,3, Carroll KR², Overcast GR^1,2,3, Philip NH⁵, Oberst A⁶, Chervonsky AV⁷, Katz JD^2,8, Pasare C^9,10,11.

1. Immunology Graduate Program, University of Texas Southwestern Medical Center, Dallas, TX, USA.
2. Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
3. Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
4. F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA, USA.
5. Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
6. Department of Immunology, University of Washington, Seattle, WA, USA.
7. Department of Pathology, University of Chicago, Chicago, IL, USA.
8. Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, USA.
9. Division of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. chandrashekhar.pasare@cchmc.org.
10. Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. chandrashekhar.pasare@cchmc.org.
11. Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH, USA. chandrashekhar.pasare@cchmc.org.

Presented by Aakanksha Jain