IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.

Cell Host Microbe. 2019 Jun 12;25(6):858-872.e13.

Hotter D¹, Bosso M¹, Jønsson KL², Krapp C³, Stürzel CM¹, Das A⁴, Littwitz-Salomon E⁵, Berkhout B⁴, Russ A⁶, Wittmann S⁶, Gramberg T⁶, Zheng Y⁷, Martins LJ⁷, Planelles V⁷, Jakobsen MR², Hahn BH⁸, Dittmer U⁵, Sauter D¹, Kirchhoff F⁹.

1. Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
2. Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
3. Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
4. Laboratory of Experimental Virology, Department of Medical Microbiology, University of Amsterdam, 1105 Amsterdam, the Netherlands.
5. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
6. Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
7. Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
8. Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
9. Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. Electronic address: frank.kirchhoff@uni-ulm.de.

Presented by Matteo Bosso