Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.
Anthony-Gonda K1, #, Bardhi A2, #, Ray A2, Flerin N2, Li M2, Chen W3, Ochsenbauer C4, Kappes JC4, 5, Krueger W1, Worden A1, Schneider D1, Zhu Z1, Orentas R1, Dimitrov DS6, Goldstein H7, Dropulić B8.
#Contributed equally
- Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
- Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
- Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
- Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
- Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35294, USA.
- Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.
- Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.
- Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.
Presented by Kim Anthony-Gonda