Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.

Sci Transl Med. 2019 Aug 7;11(504).

Anthony-Gonda K^{1, #}, Bardhi A^{2, #}, Ray A², Flerin N², Li M², Chen W³, Ochsenbauer C⁴, Kappes JC^{4, 5}, Krueger W¹, Worden A¹, Schneider D¹, Zhu Z¹, Orentas R¹, Dimitrov DS⁶, Goldstein H⁷, Dropulić B⁸.

#Contributed equally

1. Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA.
2. Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
3. Protein Interactions Section, Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21702, USA.
4. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
5. Birmingham Veterans Affairs Medical Center, Research Service, Birmingham, AL 35294, USA.
6. Center for Antibody Therapeutics, University of Pittsburgh, Pittsburgh, PA 15261, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.
7. Department of Microbiology and Immunology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.
8. Lentigen, a Miltenyi Biotec Company, Gaithersburg, MD 20878, USA. boro.dropulic@lentigen.com harris.goldstein@einstein.yu.edu dsd116@pitt.edu.

Presented by Kim Anthony-Gonda