Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women

Cell. 2019 Jun 27;178(1):190-201.e11.

Martinez DR¹, Fong Y², Li SH³, Yang F⁴, Jennewein MF⁵, Weiner JA⁶, Harrell EA⁴, Mangold JF³, Goswami R³, Seage GR 3rd⁷, Alter G⁵, Ackerman ME⁶, Peng X⁸, Fouda GG⁹, Permar SR¹⁰.

1. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
2. Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
3. Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA.
4. Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA.
5. Ragon Institute of the Massachusetts General Hospital, MIT and Harvard, Cambridge, MA 02139, USA.
6. Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA.
7. Department of Epidemiology, Harvard T.H. School of Public Health, Boston, MA 02115, USA.
8. Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27607, USA; Bioinformatics Graduate Program, North Carolina State University, Raleigh, NC 27607, USA; Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27607, USA.
9. Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA; Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: genevieve.fouda@duke.edu.
10. Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, USA; Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: sallie.permar@duke.edu.

Presented by David R Martinez