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Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Nature. 2019 Apr;568(7752):415-419.

Lu M1, Ma X1, Castillo-Menendez LR2,3, Gorman J4, Alsahafi N5,6, Ermel U1, Terry DS7, Chambers M4, Peng D4, Zhang B4, Zhou T4, Reichard N1, Wang K1, Grover JR1, Carman BP1, Gardner MR8, Nikić-Spiegel I9, Sugawara A10, Arthos J11, Lemke EA12,13,14, Smith AB 3rd10, Farzan M8, Abrams C15, Munro JB16, McDermott AB4, Finzi A5,6, Kwong PD4, Blanchard SC17, Sodroski JG18,19, Mothes W20.

  1. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
  2. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
  3. Department of Microbiology, Harvard Medical School, Boston, MA, USA.
  4. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  5. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
  6. Centre de Recherche du CHUM (CRCHUM), Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
  7. Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
  8. Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
  9. Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany.
  10. Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
  11. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  12. Departments of Biology and Chemistry, Pharmacy and Geosciences, Johannes Gutenberg University Mainz, Mainz, Germany.
  13. Institute of Molecular Biology (IMB), Johannes Gutenberg University Mainz, Mainz, Germany.
  14. Structural and Computational Biology Unit and Cell Biology and Biophysics Unit, EMBL, Heidelberg, Germany.
  15. Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA, USA.
  16. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
  17. Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. scb2005@med.cornell.edu.
  18. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Joseph_Sodroski@dfci.harvard.edu.
  19. Department of Microbiology, Harvard Medical School, Boston, MA, USA. Joseph_Sodroski@dfci.harvard.edu.
  20. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA. walther.mothes@yale.edu.

Presented by Maolin Lu