Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Nature. 2019 Apr;568(7752):415-419.

Lu M¹, Ma X¹, Castillo-Menendez LR^2,3, Gorman J⁴, Alsahafi N^5,6, Ermel U¹, Terry DS⁷, Chambers M⁴, Peng D⁴, Zhang B⁴, Zhou T⁴, Reichard N¹, Wang K¹, Grover JR¹, Carman BP¹, Gardner MR⁸, Nikić-Spiegel I⁹, Sugawara A¹⁰, Arthos J¹¹, Lemke EA^12,13,14, Smith AB 3rd¹⁰, Farzan M⁸, Abrams C¹⁵, Munro JB¹⁶, McDermott AB⁴, Finzi A^5,6, Kwong PD⁴, Blanchard SC¹⁷, Sodroski JG^18,19, Mothes W²⁰.

1. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.
2. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA.
3. Department of Microbiology, Harvard Medical School, Boston, MA, USA.
4. Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
5. Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
6. Centre de Recherche du CHUM (CRCHUM), Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada.
7. Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA.
8. Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, USA.
9. Werner Reichardt Centre for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany.
10. Department of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
11. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
12. Departments of Biology and Chemistry, Pharmacy and Geosciences, Johannes Gutenberg University Mainz, Mainz, Germany.
13. Institute of Molecular Biology (IMB), Johannes Gutenberg University Mainz, Mainz, Germany.
14. Structural and Computational Biology Unit and Cell Biology and Biophysics Unit, EMBL, Heidelberg, Germany.
15. Department of Chemical and Biological Engineering, Drexel University, Philadelphia, PA, USA.
16. Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA, USA.
17. Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. scb2005@med.cornell.edu.
18. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA. Joseph_Sodroski@dfci.harvard.edu.
19. Department of Microbiology, Harvard Medical School, Boston, MA, USA. Joseph_Sodroski@dfci.harvard.edu.
20. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA. walther.mothes@yale.edu.

Presented by Maolin Lu