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IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation.

Cell Host Microbe. 2019 Jun 12;25(6):858-872.e13.

Hotter D1, Bosso M1, Jønsson KL2, Krapp C3, Stürzel CM1, Das A4, Littwitz-Salomon E5, Berkhout B4, Russ A6, Wittmann S6, Gramberg T6, Zheng Y7, Martins LJ7, Planelles V7, Jakobsen MR2, Hahn BH8, Dittmer U5, Sauter D1, Kirchhoff F9.

  1. Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.
  2. Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
  3. Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; Department of Biomedicine, Aarhus University, 8000 Aarhus, Denmark.
  4. Laboratory of Experimental Virology, Department of Medical Microbiology, University of Amsterdam, 1105 Amsterdam, the Netherlands.
  5. Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
  6. Institute of Clinical and Molecular Virology, Friedrich-Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
  7. Division of Microbiology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
  8. Departments of Medicine and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  9. Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. Electronic address: frank.kirchhoff@uni-ulm.de.

Presented by Matteo Bosso