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Low-grade astrocytoma mutations in IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via repression of SOX2.

Victoria Fang

Cell Reports 2017 Oct 31;21(5):1267-1280.

Modrek AS1, Golub D1, Khan T1, Bready D1, Prado J1, Bowman C2, Deng J3, Zhang G3, Rocha PP2, Raviram R2, Lazaris C4, Stafford JM5, LeRoy G5, Kader M1, Dhaliwal J1, Bayin NS6, Frenster JD6, Serrano J2, Chiriboga L2, Baitalmal R2, Nanjangud G7, Chi AS8, Golfinos JG9, Wang J10, Karajannis MA11, Bonneau RA12, Reinberg D13, Tsirigos A4, Zagzag D14, Snuderl M15, Skok JA2, Neubert TA3, Placantonakis DG16.

  1. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA.
  2. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.
  3. Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
  4. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Applied Bioinformatics Center, NYU School of Medicine, New York, NY 10016, USA.
  5. Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA.
  6. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
  7. Molecular Cytogenetics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  8. Department of Neurology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
  9. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
  10. Department of Anesthesiology, NYU School of Medicine, New York, NY 10016, USA.
  11. Department of Pediatrics, NYU School of Medicine, New York, NY 10016, USA; Department of Otolaryngology, NYU School of Medicine, New York, NY 10016, USA.
  12. Department of Biology, New York University, New York, New York, 10003, USA; Department of Computer Science, New York University, New York, New York, 10003, USA; Simons Center for Data Analysis, New York, NY 10010, USA.
  13. Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
  14. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
  15. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Department of Neurology, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
  16. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA; Neuroscience Institute, NYU School of Medicine, New York, NY 10016, USA.

Presented by Aram Modrek