Low-grade astrocytoma mutations in IDH1, P53 and ATRX cooperate to block differentiation of human neural stem cells via repression of SOX2.

Cell Reports 2017 Oct 31;21(5):1267-1280.

Modrek AS¹, Golub D¹, Khan T¹, Bready D¹, Prado J¹, Bowman C², Deng J³, Zhang G³, Rocha PP², Raviram R², Lazaris C⁴, Stafford JM⁵, LeRoy G⁵, Kader M¹, Dhaliwal J¹, Bayin NS⁶, Frenster JD⁶, Serrano J², Chiriboga L², Baitalmal R², Nanjangud G⁷, Chi AS⁸, Golfinos JG⁹, Wang J¹⁰, Karajannis MA¹¹, Bonneau RA¹², Reinberg D¹³, Tsirigos A⁴, Zagzag D¹⁴, Snuderl M¹⁵, Skok JA², Neubert TA³, Placantonakis DG¹⁶.

1. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA.
2. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA.
3. Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
4. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Applied Bioinformatics Center, NYU School of Medicine, New York, NY 10016, USA.
5. Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA.
6. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA.
7. Molecular Cytogenetics Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
8. Department of Neurology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
9. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
10. Department of Anesthesiology, NYU School of Medicine, New York, NY 10016, USA.
11. Department of Pediatrics, NYU School of Medicine, New York, NY 10016, USA; Department of Otolaryngology, NYU School of Medicine, New York, NY 10016, USA.
12. Department of Biology, New York University, New York, New York, 10003, USA; Department of Computer Science, New York University, New York, New York, 10003, USA; Simons Center for Data Analysis, New York, NY 10010, USA.
13. Department of Biochemistry and Molecular Pharmacology, NYU School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
14. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
15. Department of Pathology, NYU School of Medicine, New York, NY 10016, USA; Department of Neurology, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA.
16. Department of Neurosurgery, NYU School of Medicine, New York, NY 10016, USA; Kimmel Center for Stem Cell Biology, NYU School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA; Brain Tumor Center, NYU School of Medicine, New York, NY 10016, USA; Neuroscience Institute, NYU School of Medicine, New York, NY 10016, USA.

Presented by Aram Modrek