Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal

Nat Immunol. 2019 Jan 21;20(3):265-275.

Liu M¹, O'Connor RS², Trefely S^{3, 4}, Graham K¹, Snyder NW³, Beatty GL^{5, 6}.

1. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.
2. Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
3. AJ Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
4. Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
5. Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA. gregory.beatty@uphs.upenn.edu.
6. Division of Hematology-Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. gregory.beatty@uphs.upenn.edu.

Presented by Jason Mingen Liu