Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

Dev Cell. 2019 Sep 23;50(6):690-703.e6.

Towers CG¹, Fitzwalter BE¹, Regan D², Goodspeed A³, Morgan MJ¹, Liu CW⁴, Gustafson DL⁵, Thorburn A⁶.

1. Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
2. Flint Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA; Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
3. Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; University of Colorado Comprehensive Cancer Center, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
4. Department of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
5. Flint Animal Cancer Center, Department of Clinical Sciences, Colorado State University, Fort Collins, CO 80523, USA.
6. Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address: andrew.thorburn@ucdenver.edu.

Presented by Christina Towers