Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway

Guo X1, 2, Aviles G1, 2 , Liu Y3, Tian R1, 2, 4, Unger BA2, 5, Lin YT6, Wiita AP6, Xu K2, 5, Correia MA3, 7, 8, 9, Kampmann M10, 11, 12.

  1. Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA.
  2. Chan Zuckerberg Biohub, San Francisco, CA, USA.
  3. Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA, USA.
  4. Biophysics Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
  5. Department of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
  6. Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA.
  7. Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, USA.
  8. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
  9. The Liver Center, University of California, San Francisco, San Francisco, CA, USA.
  10. Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.
  11. Chan Zuckerberg Biohub, San Francisco, CA, USA. martin.kampmann@ucsf.edu.
  12. Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA, USA. martin.kampmann@ucsf.edu.

Presented by Xiaoyan Guo

Biochemistry, Cell & Developmental BioVictoria Fang2020- 03 (Mar)