High Dietary Sugar Reshapes Sweet Taste to Promote Feeding Behavior in Drosophila melanogaster

Cell Rep. 2019 May 7;27(6):1675-1685.e7

May CE¹, Vaziri A², Lin YQ³, Grushko O⁴, Khabiri M⁵, Wang QP⁶, Holme KJ⁷, Pletcher SD⁷, Freddolino PL⁸, Neely GG³, Dus M⁹.

1. Neuroscience Graduate Program, The University of Michigan, Ann Arbor, MI 48109, USA.
2. Molecular, Cellular, and Developmental Biology Graduate Program, The University of Michigan, Ann Arbor, MI 48109, USA.
3. The Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
4. Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA.
5. Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA.
6. The Dr. John and Anne Chong Lab for Functional Genomics, Charles Perkins Centre and School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia; School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510275, PR China.
7. Physiology Graduate Program, Department of Molecular & Integrative Physiology, The University of Michigan Medical School, Ann Arbor, MI 48109, USA.
8. Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, The University of Michigan, Ann Arbor, MI 48109, USA.
9. Neuroscience Graduate Program, The University of Michigan, Ann Arbor, MI 48109, USA; Molecular, Cellular, and Developmental Biology Graduate Program, The University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular, Cellular, and Developmental Biology, The University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: mdus@umich.edu.

Presented by Christina May