Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

Cheng CW1, Biton M2, Haber AL3, Gunduz N4, Eng G5, Gaynor LT6, Tripathi S1, Calibasi-Kocal G7, Rickelt S1, Butty VL8, Moreno-Serrano M1, Iqbal AM1, Bauer-Rowe KE1, Imada S9, Ulutas MS10, Mylonas C11, Whary MT12, Levine SS8, Basbinar Y13, Hynes RO14, Mino-Kenudson M15, Deshpande V15, Boyer LA11, Fox JG12, Terranova C16, Rai K16, Piwnica-Worms H17, Mihaylova MM18, Regev A19, Yilmaz ÖH20.

  1. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
  2. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  3. Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.
  4. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University, 06800 Ankara, Turkey.
  5. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.
  6. Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.
  7. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Dokuz Eylul University, Institute of Oncology, Department of Translational Oncology, Izmir, Turkey.
  8. BioMicro Center at MIT, Department of Biology, MIT, Cambridge, MA 02139, USA.
  9. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
  10. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, Siirt University, Science and Arts Faculty, 56100 Siirt, Turkey.
  11. Department of Biology, MIT, Cambridge, MA 02139, USA.
  12. Division of Comparative Medicine, Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
  13. Dokuz Eylul University, Institute of Oncology, Department of Translational Oncology, Izmir, Turkey.
  14. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA.
  15. Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA.
  16. Genomic Medicine Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  17. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  18. Department of Biological Chemistry and Pharmacology, The Ohio State University, Columbus, OH 43210 USA.
  19. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, MIT, Cambridge, MA 02139, USA.
  20. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA; Department of Pathology, Massachusetts General Hospital Boston and Harvard Medical School, Boston, MA 02114, USA; Klarman Cell Observatory, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: ohyilmaz@mit.edu.

Presented by Chia-Wei Cheng

Metabolism, Cell & Developmental BioVictoria Fang2019-08 (Aug)