The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis.

Mattiola I 1, 2, 3, 4, 5, Tomay F1, 5, De Pizzol M1, 5, 6, Silva-Gomes R1, 7, Savino B1, 5, Gulic T1, 5, 8, Doni A1, Lonardi S9, Astrid Boutet M10, Nerviani A10, Carriero R1, Molgora M11, 12, Stravalaci M11, Morone D1, 13, Shalova IN14, Lee Y14, Biswas SK14, Mantovani G15, Sironi M1, Pitzalis C10, Vermi W9, 12, Bottazzi B1, Mantovani A16, 17, 18, Locati M19, 20.

  1. Humanitas Clinical and Research Center, Scientific Institute for Research and Healthcare, Rozzano, Italy.
  2. Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  3. Berlin Institute of Health, Berlin, Germany.
  4. Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, Berlin, Germany.
  5. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy.
  6. Dompé Farmaceutici, Milan, Italy.
  7. Graduate Program in Areas of Basic and Applied Biology, Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
  8. Medical Faculty, Department of Physiology and Immunology, University of Rijeka, Rijeka, Croatia.
  9. Department of Molecular and Translational Medicine, School of Medicine, University of Brescia, Brescia, Italy.
  10. Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  11. Humanitas University, Pieve Emanuele, Italy.
  12. Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
  13. Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
  14. Singapore Immunology Network, Agency for Science, Technology & Research, Singapore, Singapore.
  15. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Endocrinology Unit, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
  16. Humanitas Clinical and Research Center, Scientific Institute for Research and Healthcare, Rozzano, Italy. alberto.mantovani@humanitasresearch.it.
  17. Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
  18. Humanitas University, Pieve Emanuele, Italy.
  19. Humanitas Clinical and Research Center, Scientific Institute for Research and Healthcare, Rozzano, Italy.
  20. Department of Medical Biotechnologies and Translational Medicine, University of Milan, Milan, Italy. massimo.locati@humanitasresearch.it.

Presented by Irene Mattiola

Immunology & Microbiology, Cancer BiologyVictoria Fang2019-08 (Aug)