Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models.

Cruz Hernández JC1, #, Bracko O1, #, Kersbergen CJ1, Muse V1, Haft-Javaherian M1, Berg M2, Park L3, Vinarcsik LK1, Ivasyk I1, Rivera DA1, Kang Y1, Cortes-Canteli M4, 5, Peyrounette M2, Doyeux V2, Smith A2, Zhou J1, Otte G1, Beverly JD1, Davenport E1, Davit Y2, Lin CP6, Strickland S4, Iadecola C3, Lorthois S1, 2, Nishimura N7, Schaffer CB8.

  1. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA.
  2. Institut de Mécanique des Fluides de Toulouse, Université de Toulouse, CNRS, INPT, UPS, Toulouse, France.
  3. Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
  4. Patricia and John Rosenwald Laboratory for Neurobiology and Genetics, The Rockefeller University, New York, NY, USA.
  5. Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
  6. Wellman Center for Photomedicine and Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  7. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. nn62@cornell.edu.
  8. Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USA. cs385@cornell.edu.

#Contributed equally

Presented by Oliver Bracko