Adaptive mutability of colorectal cancers in response to targeted therapies.

Science. 2019 Dec 20;366(6472):1473-1480.

Russo M^{1, 2}, Crisafulli G^{2, 3}, Sogari A^{2, 3}, Reilly NM⁴, Arena S^{2, 3}, Lamba S³, Bartolini A³, Amodio V^{2, 3}, Magrì A^{2, 3}, Novara L³, Sarotto I³, Nagel ZD⁵, Piett CG⁵, Amatu A^{6, 7}, Sartore-Bianchi A^{6, 7}, Siena S^{6, 7}, Bertotti A^{2, 3}, Trusolino L^{2, 3}, Corigliano M^{8, 9}, Gherardi M^{8, 9}, Lagomarsino MC^{8, 9}, Di Nicolantonio F^{2, 3}, Bardelli A^{1, 2}.

1. Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO) 10060, Italy. alberto.bardelli@unito.it mariangela.russo@unito.it.
2. Department of Oncology, University of Torino, Candiolo (TO) 10060, Italy.
3. Candiolo Cancer Institute, FPO-IRCCS, Candiolo (TO) 10060, Italy.
4. Fondazione Piemontese per la Ricerca sul Cancro ONLUS, Candiolo (TO) 10060, Italy.
5. Department of Environmental Health, JBL Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
6. Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy.
7. Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, 20133 Milan, Italy.
8. IFOM-FIRC Institute of Molecular Oncology, 20139 Milan, Italy.
9. Department of Physics, Università degli Studi di Milano, and I.N.F.N., 20133 Milan, Italy.

Presented by Mariangela Russo