Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis.

Nat Neurosci. 2019 Aug;22(8):1248-1257.

Henderson MX¹, Cornblath EJ^{2, 3}, Darwich A⁴, Zhang B⁴, Brown H⁴, Gathagan RJ⁴, Sandler RM⁴, Bassett DS^{2, 5, 6, 7, 8}, Trojanowski JQ⁴, Lee VMY⁴.

1. Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. hendm@pennmedicine.upenn.edu.
2. Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.
3. Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
4. Institute on Aging and Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
5. Department of Electrical and Systems Engineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.
6. Department of Physics and Astronomy, College of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
7. Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
8. Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Presented by Michael Henderson