TREM2 function impedes tau seeding in neuritic plaques.

Nat Neurosci. 2019 Aug;22(8):1217-1222.

Leyns CEG^1,2,3#, Gratuze M^1,2,3#, Narasimhan S⁴, Jain N^1,2,3, Koscal LJ^1,2,3, Jiang H^1,2,3, Manis M^1,2,3, Colonna M^2,3,5, Lee VMY⁴, Ulrich JD^6,7,8, Holtzman DM^9,10,11.

1. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.
2. Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA.
3. Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
4. Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
5. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
6. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. ulrichjd@wustl.edu.
7. Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. ulrichjd@wustl.edu.
8. Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. ulrichjd@wustl.edu.
9. Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. holtzman@wustl.edu.
10. Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO, USA. holtzman@wustl.edu.
11. Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA. holtzman@wustl.edu.

#Contributed equally

Presented by Cheryl Leyns