Dietary fructose improves intestinal cell survival and nutrient absorption

Nature. 2021 Sep;597(7875):263-267. doi: 10.1038/s41586-021-03827-2.

Samuel R Taylor, Shakti Ramsamooj, Roger J Liang ... Lewis C Cantley, Kyu Y Rhee, Marcus D Goncalves

Metabolism, Cancer Biology, BiochemistryNicholas LiaoDecember 7, 20212021-09 (Sep)

Small RNAs are modified with N-glycans and displayed on the surface of living cells

Cell. 2021 Jun 10;184(12):3109-3124.e22. doi: 10.1016/j.cell.2021.04.023.

Ryan A Flynn, Kayvon Pedram, Stacy A Malaker ... Peter W Villalta, Jan E Carette, Carolyn R Bertozzi

Biochemistry, Cell & Developmental BioNicholas LiaoDecember 1, 20212021-06 (Jun)

Dual film-like organelles enable spatial separation of orthogonal eukaryotic translation

Cell. 2021 Sep 16;184(19):4886-4903.e21. doi: 10.1016/j.cell.2021.08.001.

Christopher D Reinkemeier, Edward A Lemke

Biochemistry, BiotechnologyNicholas LiaoOctober 28, 20212021-08 (Aug)

DNA-driven condensation assembles the meiotic DNA break machinery

Nature. 2021 Apr;592(7852):144-149. doi: 10.1038/s41586-021-03374-w.

Corentin Claeys Bouuaert, Stephen Pu, Juncheng Wang ... Wei Xie, Dinshaw J Patel, Scott Keeney

Genetics & Genome Biology, Cell & Developmental Bio, BiochemistryNicholas LiaoOctober 21, 20212021-04 (Apr)

Creatine kinase B controls futile creatine cycling in thermogenic fat

Nature. 2021 Feb;590(7846):480-485. doi: 10.1038/s41586-021-03221-y.

Janane F Rahbani, Anna Roesler, Mohammed F Hussain ... Karen Reue, Bruce M Spiegelman, Lawrence Kazak

BiochemistryNicholas LiaoOctober 14, 20212021-02 (Feb)

Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling

Nat Commun. 2020 Nov 17;11(1):5832. doi: 10.1038/s41467-020-19445-x.

Anna M Kotowska, Gustavo F Trindade, Paula M Mendes ... Alexander G Shard, Morgan R Alexander, David J Scurr

Biochemistry, BiotechnologyNicholas LiaoAugust 3, 20212020-11 (Nov)

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

Nat Commun. 2020 Nov 30;11(1):6088. doi: 10.1038/s41467-020-19937-w.

Xin Zhou, Yanghao Zhong, Olivia Molinar-Inglis ... JoAnn Trejo, Alexandra C Newton, Jin Zhang

Biochemistry, Cell & Developmental BioNicholas LiaoJuly 20, 20212020-11 (Nov)

Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

Nat Commun. 2020 Dec 1;11(1):6141. doi: 10.1038/s41467-020-19921-4.

Jan Zrimec, Christoph S Börlin, Filip Buric ... Jens Nielsen, Mats Töpel, Aleksej Zelezniak

Biochemistry, Genetics & Genome BiologyNicholas LiaoMay 27, 20212020-12 (Dec)

Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ

Nat Methods. 2020 May;17(5):515-523. doi: 10.1038/s41592-020-0797-9.

Tong Wu, Ruitu Lyu, Qiancheng You, Chuan He

Genomics, Biotechnology, BiochemistryNicholas LiaoMay 24, 20212020-05 (May)

Small-molecule-induced polymerization triggers degradation of BCL6

Nature. 2020 Dec;588(7836):164-168. doi: 10.1038/s41586-020-2925-1.

Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel ... Radosław P Nowak, Eric S Fischer, Benjamin L Ebert

BiochemistryNicholas LiaoMay 20, 20212020-12 (Dec)

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

Cell Metab. 2021 Mar 2;33(3):629-648.e10. doi: 10.1016/j.cmet.2020.12.003.

Ahmad A Cluntun, Rachit Badolia, Sandra Lettlova ... Stephen H McKellar, Jared Rutter, Stavros G Drakos

Biochemistry, MetabolismNicholas LiaoApril 13, 20212021-03 (Mar)

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease

Sci Transl Med. 2020 Dec 9;12(573):eabb1206. doi: 10.1126/scitranslmed.abb1206.

Anamitra Ghosh, Michele M Comerota, Debin Wan ... Sung Hee Hwang, Bruce D Hammock, Hui Zheng

Neuroscience, Biochemistry, MedicineNicholas LiaoApril 8, 20212020-12 (Dec)

Identification of the human DPR core promoter element using machine learning

Nature. 2020 Sep;585(7825):459-463. doi: 10.1038/s41586-020-2689-7.

Long Vo Ngoc, Cassidy Yunjing Huang, California Jack Cassidy, Claudia Medrano, James T Kadonaga

Biochemistry, BiotechnologyNicholas LiaoMarch 11, 20212020-09 (Sep)

IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

Nature. 2020 Dec;588(7838):491-497. doi: 10.1038/s41586-020-2884-6.

Jaewoong Lee, Mark E Robinson, Ning Ma ... Michael S Diamond, Nagarajan Vaidehi, Markus Müschen

Biochemistry, Immunology & Microbiology, Cancer BiologyNicholas LiaoDecember 29, 20202020-12 (Dec)

ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

Cell Rep. 2020 Sep 1;32(9):108096. doi: 10.1016/j.celrep.2020.108096.

Michael D Rainey, Declan Bennett, Rachel O'Dea ... Muriel Voisin, Cathal Seoighe, Corrado Santocanale

Biochemistry, Cell & Developmental BioNicholas LiaoDecember 3, 20202020-09 (Sep)

CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage

EMBO Rep. 2020 Aug 5;21(8):e48920. doi: 10.15252/embr.201948920.

Michael D Rainey, Aisling Quinlan, Chiara Cazzaniga ... Anja Göder, Massimo Lopes, Corrado Santocanale

Biochemistry, Cancer BiologyNicholas LiaoDecember 1, 20202020-08 (Aug)

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

Cell. 2020 Sep 17;182(6):1531-1544.e15. doi: 10.1016/j.cell.2020.07.043.

Jason Z Zhang, Tsan-Wen Lu, Lucas M Stolerman ... Susan S Taylor, Sohum Mehta, Jin Zhang

Cancer Biology, BiochemistryNicholas LiaoNovember 12, 20202020-09 (Sep)

Promotion of Axon Growth by the Secreted End of a Transcription Factor

Cell Rep. 2019 Oct 8;29(2):363-377.e5. doi: 10.1016/j.celrep.2019.08.101.

Ethan P McCurdy, Kyung Min Chung, Carlos R Benitez-Agosto, Ulrich Hengst

Neuroscience, BiochemistryNicholas LiaoOctober 8, 20202019-10