Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

Nat Commun. 2020 Dec 1;11(1):6141. doi: 10.1038/s41467-020-19921-4.

Jan Zrimec, Christoph S Börlin, Filip Buric ... Jens Nielsen, Mats Töpel, Aleksej Zelezniak

Biochemistry, Genetics & Genome BiologyNicholas LiaoMay 27, 20212020-12 (Dec)

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

Cell. 2020 Dec 10;183(6):1617-1633.e22. doi: 10.1016/j.cell.2020.11.012.

Carol C L Chen, Shriya Deshmukh, Selin Jessa ... Paolo Salomoni, Claudia L Kleinman, Nada Jabado

Medicine, Cancer Biology, Genetics & Genome BiologyNicholas LiaoApril 27, 20212020-12 (Dec)

Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis

Sci Transl Med. 2020 May 27;12(545):eaay1548. doi: 10.1126/scitranslmed.aay1548.

Rachel Knevel, Saskia le Cessie, Chikashi C Terao ... Katherine P Liao, Elizabeth W Karlson, Soumya Raychaudhuri

Genetics & Genome BiologyNicholas LiaoApril 1, 20212020-05 (May)

Genetic tool development in marine protists: emerging model organisms for experimental cell biology

Nat Methods. 2020 May;17(5):481-494. doi: 10.1038/s41592-020-0796-x.

Drahomíra Faktorová, R Ellen R Nisbet, José A Fernández Robledo ... Thomas Mock, Alexandra Z Worden, Julius Lukeš

Genetics & Genome Biology, BiotechnologyNicholas LiaoMarch 30, 20212020-05 (May)

A yeast living ancestor reveals the origin of genomic introgressions

Nature. 2020 Nov;587(7834):420-425. doi: 10.1038/s41586-020-2889-1.

Melania D'Angiolo, Matteo De Chiara, Jia-Xing Yue ... Eric Gilson, Jonas Warringer, Gianni Liti

Genetics & Genome BiologyNicholas LiaoDecember 24, 20202020-11 (Nov)

Optimization of AsCas12a for combinatorial genetic screens in human cells

Nat Biotechnol. 2020 Jul 13. doi: 10.1038/s41587-020-0600-6.

Peter C DeWeirdt, Kendall R Sanson, Annabel K Sangree ... Xuewen Pan, Alan Huang, John G Doench

Biotechnology, Genetics & Genome BiologyNicholas LiaoDecember 17, 20202020-07 (Jul)

Automated design of thousands of nonrepetitive parts for engineering stable genetic systems

Nat Biotechnol. 2020 Dec;38(12):1466-1475. doi: 10.1038/s41587-020-0584-2.

Ayaan Hossain, Eriberto Lopez, Sean M Halper ... Devin Strickland, Eric Klavins, Howard M Salis

Biotechnology, Genetics & Genome BiologyNicholas LiaoDecember 9, 20202020-12 (Dec)

A genetic mechanism for sexual dichromatism in birds

Science. 2020 Jun 12;368(6496):1270-1274. doi: 10.1126/science.aba0803.

Małgorzata A Gazda, Pedro M Araújo, Ricardo J Lopes ... Geoffrey E Hill, Joseph C Corbo, Miguel Carneiro

Genetics & Genome BiologyNicholas LiaoNovember 10, 20202020-06 (Jun)

CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response

Nat Genet. 2020 Jul;52(7):655-661. doi: 10.1038/s41588-020-0643-0.

Grégoire Stik, Enrique Vidal, Mercedes Barrero ... Marc A Marti-Renom, Ralph Stadhouders, Thomas Graf

Genomics, Immunology & Microbiology, Genetics & Genome BiologyNicholas LiaoOctober 1, 20202020-07 (Jul)

Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Nat Genet. 2020 Jul;52(7):662-668. doi: 10.1038/s41588-020-0623-4.

Oana M Enache, Veronica Rendo, Mai Abdusamad ... Rameen Beroukhim, Todd R Golub, Uri Ben-David

Genetics & Genome Biology, GenomicsNicholas LiaoSeptember 23, 20202020-07 (Jul)

Autism risk in offspring can be assessed through quantification of male sperm mosaicism

Nat Med. 2020 Jan;26(1):143-150. doi: 10.1038/s41591-019-0711-0.

Martin W Breuss, Danny Antaki, Renee D George ... Melissa Gymrek, Jonathan Sebat, Joseph G Gleeson

Genetics & Genome Biology, GenomicsNicholas LiaoAugust 6, 20202020-01 (Jan)

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Dev Cell. 2019 Oct 7;51(1):21-34.e5. doi: 10.1016/j.devcel.2019.07.023.

Soichiro Yamanaka, Hidenori Nishihara, Hidehiro Toh ... Piero Carninci, Hiroyuki Sasaki, Haruhiko Siomi

Genetics & Genome BiologyNicholas LiaoJune 19, 20202019-10 (Oct)

Detection of Deleterious On-Target Effects After HDR-Mediated CRISPR Editing

Cell Rep. 2020 May 26;31(8):107689.

Isabel Weisheit, Joseph A Kroeger, Rainer Malik ... Angelika Dannert, Martin Dichgans, Dominik Paquet

Genetics & Genome Biology, BiotechnologyNicholas LiaoJune 17, 20202020-05 (May)

HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

Mol Cell. 2019 Aug 22;75(4):711-724.e5. doi: 10.1016/j.molcel.2019.05.034.

Joshua J Gruber, Benjamin Geller, Andrew M Lipchik ... James M Ford, Calvin J Kuo, Michael P Snyder

Biochemistry, Metabolism, Genetics & Genome BiologyNicholas LiaoJune 13, 20202019-08 (Aug)

RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats.

Nat Neurosci. 2019 Sep;22(9):1383-1388.

Yamada SB, Gendron TF, Niccoli T, Isaacs AM, Petrucelli L, Gitler AD.

Neuroscience, Genetics & Genome BiologyNicholas LiaoMay 27, 20202019-09 (Sep)

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.

Nat Biotechnol. 2020 Jan;38(1):50-55.

Kyle V Butler, Anna M Chiarella, Berkley E Gryder ... Javed Khan, Jian Jin, Nathaniel A Hathaway

Genomics, Biochemistry, Genetics & Genome BiologyNicholas LiaoMay 25, 20202020-01 (Jan)

LncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

Mol Cell. 2019 Aug 8;75(3):523-537.e10.

Schertzer MD, Braceros KCA, Starmer J, Dowen JM, Magnuson T, Calabrese JM.

Cell & Developmental Bio, Genetics & Genome BiologyNicholas LiaoApril 30, 20202019-08 (Aug)

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

Cancer Cell. 2019 Aug 12;36(2):139-155.e10

Su W, Han HH, Wang Y…Scher H, Ouerfelli O, Giancotti FG.