Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Nat Genet. 2020 Jul;52(7):662-668. doi: 10.1038/s41588-020-0623-4.

Oana M Enache, Veronica Rendo, Mai Abdusamad ... Rameen Beroukhim, Todd R Golub, Uri Ben-David

Genetics & Genome Biology, GenomicsNicholas LiaoSeptember 23, 20202020-07 (Jul)

Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

Cancer Cell. 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011.

Scott Ryall, Michal Zapotocky, Kohei Fukuoka ... David W Ellison, Uri Tabori, Cynthia Hawkins

Cancer Biology, GenomicsNicholas LiaoAugust 10, 202004, 2020-04 (Apr)

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Cell. 2019 Sep 5;178(6):1493-1508.e20. doi: 10.1016/j.cell.2019.08.008.

Jerome C Martin, Christie Chang, Gilles Boschetti ... Miriam Merad, Judy H Cho, Ephraim Kenigsberg

Immunology & Microbiology, GenomicsNicholas LiaoAugust 8, 20202019-09 (Sep)

Autism risk in offspring can be assessed through quantification of male sperm mosaicism

Nat Med. 2020 Jan;26(1):143-150. doi: 10.1038/s41591-019-0711-0.

Martin W Breuss, Danny Antaki, Renee D George ... Melissa Gymrek, Jonathan Sebat, Joseph G Gleeson

Genetics & Genome Biology, GenomicsNicholas LiaoAugust 6, 20202020-01 (Jan)

DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data

Cell Rep. 2019 Nov 5;29(6):1718-1727.e8. doi: 10.1016/j.celrep.2019.09.082.

Erica A K DePasquale, Daniel J Schnell, Pieter-Jan Van Camp ... H Leighton Grimes, Harinder Singh, Nathan Salomonis

Biotechnology, GenomicsNicholas LiaoAugust 5, 20202019-11 (Nov)

Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa

Cell Rep. 2019 Nov 5;29(6):1707-1717.e3. doi: 10.1016/j.celrep.2019.10.006

Zeling Xu, Ming Li, Yanran Li ... Patrick C Y Woo, Hua Xiang, Aixin Yan

Immunology & Microbiology, Genomics, BiotechnologyNicholas LiaoJuly 30, 20202019-10 (Oct)

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052.

Michele M Nava, Yekaterina A Miroshnikova, Leah C Biggs ... Carien M Niessen, Kris Noel Dahl, Sara A Wickström

Genomics, Cell & Developmental BioNicholas LiaoJuly 27, 20202020-05 (May)

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

Nat Biotechnol. 2020 Jun 29. doi: 10.1038/s41587-020-0551-y.

Samuele Ferrari, Aurelien Jacob, Stefano Beretta ... Ivan Merelli, Pietro Genovese, Luigi Naldini

Genomics, Cell & Developmental Bio, BiotechnologyNicholas LiaoJuly 23, 20202020-06 (Jun)

Obese Individuals With and Without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

Cell Host Microbe. 2019 Aug 14;26(2):252-264.e10. doi: 10.1016/j.chom.2019.07.004.

Louise B Thingholm, Malte C Rühlemann, Manja Koch ... Matthias Laudes, Andre Franke, Curtis Huttenhower

Metabolism, Medicine, Immunology & Microbiology, GenomicsNicholas LiaoJuly 13, 20202019-08 (Aug)

Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder

Cell Rep. 2019 Oct 15;29(3):764-777.e5. doi: 10.1016/j.celrep.2019.09.017.

Sebastian Lobentanzer, Geula Hanin, Jochen Klein, Hermona Soreq

Neuroscience, GenomicsNicholas LiaoJuly 10, 20202019-10 (Oct)

Mouse Models of Neutropenia Reveal Progenitor-Stage-Specific Defects

Nature. 2020 Jun;582(7810):109-114. doi: 10.1038/s41586-020-2227-7.

David E Muench, Andre Olsson, Kyle Ferchen ... Sing Sing Way, Nathan Salomonis, H Leighton Grimes

Cell & Developmental Bio, Genomics, MedicineNicholas LiaoJuly 9, 20202020-06 (Jun)

A Bioinformatic Analysis of Integrative Mobile Genetic Elements Highlights Their Role in Bacterial Adaptation

Cell Host Microbe. 2020 Jan 8;27(1):140-153.e9.

Matthew G Durrant, Michelle M Li, Benjamin A Siranosian, Stephen B Montgomery, Ami S Bhatt

Immunology & Microbiology, GenomicsNicholas LiaoJune 1, 20202020-01 (Jan)

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.

Nat Biotechnol. 2020 Jan;38(1):50-55.

Kyle V Butler, Anna M Chiarella, Berkley E Gryder ... Javed Khan, Jian Jin, Nathaniel A Hathaway

Genomics, Biochemistry, Genetics & Genome BiologyNicholas LiaoMay 25, 20202020-01 (Jan)

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

Mol Cell. 2019 May 16;74(4):688-700.e3

Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE.

Genomics, Biochemistry, Cancer BiologyNicholas LiaoApril 11, 20202019-05 (May)

Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules.

Mol Cell. 2019 Aug 22;75(4):875-887.e5.

Padrón A, Iwasaki S, Ingolia NT.

Biochemistry, Cell & Developmental Bio, GenomicsDavid CantorMarch 31, 20202019-08 (Aug)

A Reverse Ecology Approach Based on a Biological Definition of Microbial Populations

Cell. 2019 Aug 8;178(4):820-834.e14

Arevalo P, VanInsberghe D, Elsherbini J, Gore J, Polz MF.

Genomics, Medicine, Immunology & Microbiology, Genetics & Genome BiologyVictoria FangJanuary 16, 20202019-08 (Aug)

Functional dissection of the Sox9-Kcnj2 locus identifies nonessential and instructive roles of TAD architecture

Despang A, Schöpflin R, Franke M, Ali S, Jerković I, Paliou C, Chan WL, Timmermann B, Wittler L, Vingron M, Mundlos S, Ibrahim DM.

Nat Genet. 2019 Aug;51(8):1263-1271.

Genomics, Genetics & Genome BiologyVictoria FangNovember 24, 20192019-08 (Aug)

Emergence and Spread of Basal Lineages of Yersinia pestis during the Neolithic Decline.

Rascovan N, Sjögren KG, Kristiansen K, Nielsen R, Willerslev E, Desnues C, Rasmussen S.

Cell. 2019 Jan 10;176(1-2):295-305.e10.

GenomicsVictoria FangNovember 6, 20192019-01 (Jan)