Ahr-Foxp3-RORγt axis controls gut homing of CD4 + T cells by regulating GPR15

Sci Immunol. 2020 Jun 12;5(48):eaaz7277. doi: 10.1126/sciimmunol.aaz7277.

Lifeng Xiong, Joseph W Dean, Zheng Fu ... Zongming E Chen, Marcus Mühlbauer, Liang Zhou

Immunology & Microbiology, BiochemistryNicholas LiaoSeptember 30, 2020

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

Cell Metab. 2019 Jan 8;29(1):192-201.e7. doi: 10.1016/j.cmet.2018.08.013.

Sung Min Son, So Jung Park, Huikyong Lee ... Jong Eun Lee, Fiona M Menzies, David C Rubinsztein

Metabolism, BiochemistryNicholas LiaoAugust 24, 20202019-01 (Jan)

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Nat Commun. 2020 Jun 19;11(1):3150. doi: 10.1038/s41467-020-16819-z.

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski ... James M Murphy, Warren S Alexander, John Silke

Cell & Developmental Bio, Biochemistry, MedicineNicholas LiaoAugust 20, 20202020-06 (Jun)

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Nat Commun. 2020 Jun 19;11(1):3151. doi: 10.1038/s41467-020-16887-1.

Andre L Samson, Ying Zhang, Niall D Geoghegan ... Guillaume Lessene, Edwin D Hawkins, James M Murphy

Cell & Developmental Bio, BiochemistryNicholas LiaoAugust 19, 20202020-06 (Jun)

Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

Cell Rep. 2019 Dec 10;29(11):3652-3663.e5. doi: 10.1016/j.celrep.2019.11.014.

Todd Douglas, Maya Saleh

BiochemistryNicholas LiaoAugust 12, 20202019-12 (Dec)

Targeting Peripheral CB 1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis

Cell Metab. 2019 Jun 4;29(6):1320-1333.e8. doi: 10.1016/j.cmet.2019.04.012.

Grzegorz Godlewski, Resat Cinar, Nathan J Coffey ... Roy G Smith, Hiroshi Iwakura, George Kunos

Metabolism, BiochemistryNicholas LiaoJune 24, 20202019-06 (Jun)

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

Cell Metab. 2020 Feb 4;31(2):375-390.e11. doi: 10.1016/j.cmet.2019.11.019.

Paul Petrus, Simon Lecoutre, Lucile Dollet ... Myriam Aouadi, Anna Krook, Mikael Rydén

Metabolism, Biochemistry, MedicineNicholas LiaoJune 18, 20202020-02 (Feb)

HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding

Mol Cell. 2019 Aug 22;75(4):711-724.e5. doi: 10.1016/j.molcel.2019.05.034.

Joshua J Gruber, Benjamin Geller, Andrew M Lipchik ... James M Ford, Calvin J Kuo, Michael P Snyder

Biochemistry, Metabolism, Genetics & Genome BiologyNicholas LiaoJune 13, 20202019-08 (Aug)

Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery.

Nat Biotechnol. 2020 Jan;38(1):50-55.

Kyle V Butler, Anna M Chiarella, Berkley E Gryder ... Javed Khan, Jian Jin, Nathaniel A Hathaway

Genomics, Biochemistry, Genetics & Genome BiologyNicholas LiaoMay 25, 20202020-01 (Jan)

NLRP3 inflammasome activation drives tau pathology.

Nature. 2019 Nov;575(7784):669-673.

Ising C, Venegas C, Zhang S, Latz E, Buée L, Heneka MT.

Neuroscience, BiochemistryNicholas LiaoApril 28, 20202019-11 (Nov)

Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway

Nature. 2020 Mar;579(7799):427-432

Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M.

Biochemistry, Cell & Developmental BioVictoria FangApril 15, 20202020- 03 (Mar)

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

Cell. 2019 Mar 7;176(6):1490-1501.e12.

Worden EJ, Hoffmann NA, Hicks CW, Wolberger C.

Structural Biology, BiochemistryNicholas LiaoApril 13, 20202019-03 (Mar)

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

Mol Cell. 2019 May 16;74(4):688-700.e3

Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE.

Genomics, Biochemistry, Cancer BiologyNicholas LiaoApril 11, 20202019-05 (May)

Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules.

Mol Cell. 2019 Aug 22;75(4):875-887.e5.

Padrón A, Iwasaki S, Ingolia NT.

Biochemistry, Cell & Developmental Bio, GenomicsDavid CantorMarch 31, 20202019-08 (Aug)

QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25668-25676.

Qing R, Han Q, Skuhersky M, Chung H, Badr M, Schubert T, Zhang S.

Biochemistry, Structural BiologyDavid CantorMarch 27, 20202019-12 (Dec)

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Mol Cell. 2019 Apr 18;74(2):378-392.e5.

Baffi TR, Van AN, Zhao W, Mills GB, Newton AC.

Biochemistry, Cancer Biology, MedicineDavid CantorMarch 25, 20202019-04 (Apr)

The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates

Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25068-25077.

Devaraj A, Buzzo JR, Mashburn-Warren L, Gloag ES, Novotny LA, Stoodley P, Bakaletz LO, Goodman SD.

Biochemistry, Immunology & MicrobiologyVictoria FangMarch 24, 20202019-12 (Dec)

Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

Mol Cell. 2019 Oct 3;76(1):70-81.e9

Zhou KI, Shi H, Lyu R, Wylder AC, Matuszek Ż, Pan JN, He C, Parisien M, Pan T.

Biochemistry, Cell & Developmental BioVictoria FangMarch 9, 20202019-10 (Oct)