Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

Cancer Cell. 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011.

Scott Ryall, Michal Zapotocky, Kohei Fukuoka ... David W Ellison, Uri Tabori, Cynthia Hawkins

Cancer Biology, GenomicsNicholas LiaoAugust 10, 202004, 2020-04 (Apr)

Single-Cell Analysis of Crohn's Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy

Cell. 2019 Sep 5;178(6):1493-1508.e20. doi: 10.1016/j.cell.2019.08.008.

Jerome C Martin, Christie Chang, Gilles Boschetti ... Miriam Merad, Judy H Cho, Ephraim Kenigsberg

Immunology & Microbiology, GenomicsNicholas LiaoAugust 8, 20202019-09 (Sep)

Autism risk in offspring can be assessed through quantification of male sperm mosaicism

Nat Med. 2020 Jan;26(1):143-150. doi: 10.1038/s41591-019-0711-0.

Martin W Breuss, Danny Antaki, Renee D George ... Melissa Gymrek, Jonathan Sebat, Joseph G Gleeson

Genetics & Genome Biology, GenomicsNicholas LiaoAugust 6, 20202020-01 (Jan)

DoubletDecon: Deconvoluting Doublets from Single-Cell RNA-Sequencing Data

Cell Rep. 2019 Nov 5;29(6):1718-1727.e8. doi: 10.1016/j.celrep.2019.09.082.

Erica A K DePasquale, Daniel J Schnell, Pieter-Jan Van Camp ... H Leighton Grimes, Harinder Singh, Nathan Salomonis

Biotechnology, GenomicsNicholas LiaoAugust 5, 20202019-11 (Nov)

Functional Ontogeny of Hypothalamic Agrp Neurons in Neonatal Mouse Behaviors

Cell. 2019 Jun 27;178(1):44-59.e7. doi: 10.1016/j.cell.2019.04.026.

Marcelo R Zimmer, Antonio H O Fonseca, Onur Iyilikci, Rafael Dai Pra, Marcelo O Dietrich

NeuroscienceNicholas LiaoAugust 3, 20202019-06 (Jun)

Targeting leukocidin-mediated immune evasion protects mice from Staphylococcus aureus bacteremia

J Exp Med. 2020 Sep 7;217(9):e20190541. doi: 10.1084/jem.20190541.

Kayan Tam, Keenan A Lacey, Joseph C Devlin ... Sergei B Koralov, P'ng Loke, Victor J Torres

Immunology & MicrobiologyNicholas LiaoAugust 1, 20202020-09 (Sep)

Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa

Cell Rep. 2019 Nov 5;29(6):1707-1717.e3. doi: 10.1016/j.celrep.2019.10.006

Zeling Xu, Ming Li, Yanran Li ... Patrick C Y Woo, Hua Xiang, Aixin Yan

Immunology & Microbiology, Genomics, BiotechnologyNicholas LiaoJuly 30, 20202019-10 (Oct)

Fungal aerobiota are not affected by time nor environment over a 13-y time series at the Mauna Loa Observatory

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25728-25733. doi: 10.1073/pnas.1907414116.

Laura Tipton, Geoffrey Zahn, Erin Datlof ... Patrick Sheridan, Anthony S Amend, Nicole A Hynson

MicrobiologyNicholas LiaoJuly 29, 20202019-12 (Dec)

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Cell. 2020 May 14;181(4):800-817.e22. doi: 10.1016/j.cell.2020.03.052.

Michele M Nava, Yekaterina A Miroshnikova, Leah C Biggs ... Carien M Niessen, Kris Noel Dahl, Sara A Wickström

Genomics, Cell & Developmental BioNicholas LiaoJuly 27, 20202020-05 (May)

Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking

Nat Biotechnol. 2020 Jun 29. doi: 10.1038/s41587-020-0551-y.

Samuele Ferrari, Aurelien Jacob, Stefano Beretta ... Ivan Merelli, Pietro Genovese, Luigi Naldini

Genomics, Cell & Developmental Bio, BiotechnologyNicholas LiaoJuly 23, 20202020-06 (Jun)

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

Nature. 2020 Apr;580(7805):647-652. doi: 10.1038/s41586-020-2174-3.

Catherine R Lammert, Elizabeth L Frost, Calli E Bellinger ... Matt J Paysour, Hannah E Ennerfelt, John R Lukens

Neuroscience, Cell & Developmental BioNicholas LiaoJuly 22, 20202020-04 (Apr)

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors Through Inhibition of STING Signaling

Immunity. 2020 Apr 14;52(4):668-682.e7. doi: 10.1016/j.immuni.2020.03.004.

Eslam Mohamed, Rosa A Sierra, Jimena Trillo-Tinoco ... Juan R Cubillos-Ruiz, Jose R Conejo-Garcia, Paulo C Rodriguez

Cancer Biology, Metabolism, Immunology & MicrobiologyNicholas LiaoJuly 20, 20202020-04 (Apr)

NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction

Cell Metab. 2020 Jun 16;S1550-4131(20)30304-1. doi: 10.1016/j.cmet.2020.06.003.

Gregory S McElroy, Colleen R Reczek, Paul A Reyfman, Divakar S Mithal, Craig M Horbinski, Navdeep S Chandel

Metabolism, NeuroscienceNicholas LiaoJuly 16, 20202020-06 (Jun)

Platelet-derived extracellular vesicles infiltrate and modify the bone marrow during inflammation

Blood Adv. 2020 Jul 14;4(13):3011-3023. doi: 10.1182/bloodadvances.2020001758.

Shauna L French, Kirill R Butov, Isabelle Allaeys ... Eric Boilard, Mikhail A Panteleev, Kellie R Machlus

Cell & Developmental BioNicholas LiaoJuly 14, 20202020-07 (Jul)

Obese Individuals With and Without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

Cell Host Microbe. 2019 Aug 14;26(2):252-264.e10. doi: 10.1016/j.chom.2019.07.004.

Louise B Thingholm, Malte C Rühlemann, Manja Koch ... Matthias Laudes, Andre Franke, Curtis Huttenhower

Metabolism, Medicine, Immunology & Microbiology, GenomicsNicholas LiaoJuly 13, 20202019-08 (Aug)

Integrative Transcriptomics Reveals Sexually Dimorphic Control of the Cholinergic/Neurokine Interface in Schizophrenia and Bipolar Disorder

Cell Rep. 2019 Oct 15;29(3):764-777.e5. doi: 10.1016/j.celrep.2019.09.017.

Sebastian Lobentanzer, Geula Hanin, Jochen Klein, Hermona Soreq

Neuroscience, GenomicsNicholas LiaoJuly 10, 20202019-10 (Oct)

Mouse Models of Neutropenia Reveal Progenitor-Stage-Specific Defects

Nature. 2020 Jun;582(7810):109-114. doi: 10.1038/s41586-020-2227-7.

David E Muench, Andre Olsson, Kyle Ferchen ... Sing Sing Way, Nathan Salomonis, H Leighton Grimes

Cell & Developmental Bio, Genomics, MedicineNicholas LiaoJuly 9, 20202020-06 (Jun)

Multi-sample SPIM Image Acquisition, Processing and Analysis of Vascular Growth in Zebrafish

Development. 2019 Mar 21;146(6):dev173757. doi: 10.1242/dev.173757.

Stephan Daetwyler, Ulrik Günther, Carl D Modes, Kyle Harrington, Jan Huisken

Biotechnology, Cell & Developmental BioNicholas LiaoJuly 6, 20202019-03 (Mar)