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Research Films RSS
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Tunable dynamics of B cell selection in gut germinal centres
Tunable dynamics of B cell selection in gut germinal centres

Nature. 2020 Oct 28. doi: 10.1038/s41586-020-2865-9.

Carla R Nowosad, Luka Mesin, Tiago B R Castro ... Angelina M Bilate, Daniel Mucida, Gabriel D Victora

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Immunology & MicrobiologyNicholas LiaoNovember 2, 20202020-10 (Oct)
Human cognition involves the dynamic integration of neural activity and neuromodulatory systems
Human cognition involves the dynamic integration of neural activity and neuromodulatory systems

Nat Neurosci. 2019 Feb;22(2):289-296. doi: 10.1038/s41593-018-0312-0.

James M Shine, Michael Breakspear, Peter T Bell ... Oluwasanmi Koyejo, Olaf Sporns, Russell A Poldrack

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NeuroscienceNicholas LiaoOctober 29, 20202019-02 (Feb)
Activated CD8 + T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice
Activated CD8 + T Cells Cause Long-Term Neurological Impairment after Traumatic Brain Injury in Mice

Cell Rep. 2019 Oct 29;29(5):1178-1191.e6. doi: 10.1016/j.celrep.2019.09.046.

Maria Daglas, Dominik F Draxler, Heidi Ho ... Frank Alderuccio, Maithili Sashindranath, Robert L Medcalf

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Neuroscience, Immunology & MicrobiologyNicholas LiaoOctober 27, 20202019-10 (Oct)
Importin α3 regulates chronic pain pathways in peripheral sensory neurons
Importin α3 regulates chronic pain pathways in peripheral sensory neurons

Science. 2020 Aug 14;369(6505):842-846. doi: 10.1126/science.aaz5875.

Letizia Marvaldi, Nicolas Panayotis, Stefanie Alber ... Enno Hartmann, Michael Bader, Mike Fainzilber

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NeuroscienceNicholas LiaoOctober 26, 20202020-08 (Aug)
Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes

Cell Rep. 2019 Dec 3;29(10):3009-3018.e4. doi: 10.1016/j.celrep.2019.11.007.

Hamidullah Khan, Ashish Anshu, Aman Prasad ... Wasakorn Kittipongdaja, David T Yang, Stefan M Schieke

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Cancer BiologyNicholas LiaoOctober 22, 20202019-12 (Dec)
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury
Neural Stem Cell Grafts Form Extensive Synaptic Networks that Integrate with Host Circuits after Spinal Cord Injury

Cell Stem Cell. 2020 Sep 3;27(3):430-440.e5. doi: 10.1016/j.stem.2020.07.007.

Steven Ceto, Kohei J Sekiguchi, Yoshio Takashima, Axel Nimmerjahn, Mark H Tuszynski

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NeuroscienceNicholas LiaoOctober 21, 20202020-09 (Sep)
Mitochondrial ubiquinol oxidation is necessary for tumour growth
Mitochondrial ubiquinol oxidation is necessary for tumour growth

Nature. 2020 Sep;585(7824):288-292. doi: 10.1038/s41586-020-2475-6.

Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong ... Raul Piseaux, G R Scott Budinger, Navdeep S Chandel

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Cancer BiologyNicholas LiaoOctober 19, 20202020-09 (Sep)
Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization
Divergent T follicular helper cell requirement for IgA and IgE production to peanut during allergic sensitization

Sci Immunol. 2020 May 8;5(47):eaay2754. doi: 10.1126/sciimmunol.aay2754.

Biyan Zhang, Elise Liu, Jake A Gertie ... Katharina Lahl, Uthaman Gowthaman, Stephanie C Eisenbarth

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Immunology & MicrobiologyNicholas LiaoOctober 15, 20202020-05 (May)
SARS-CoV-2 seroprevalence among parturient women in Philadelphia
SARS-CoV-2 seroprevalence among parturient women in Philadelphia

Sci Immunol. 2020 Jul 29;5(49):eabd5709. doi: 10.1126/sciimmunol.abd5709.

Dustin D Flannery, Sigrid Gouma, Miren B Dhudasia ... E John Wherry, Karen M Puopolo, Scott E Hensley

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Immunology & Microbiology, Medicine, COVID-19Nicholas LiaoOctober 13, 20202020-07 (Jul)
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics
Defining the emergence of myeloid-derived suppressor cells in breast cancer using single-cell transcriptomics

Sci Immunol. 2020 Feb 21;5(44):eaay6017. doi: 10.1126/sciimmunol.aay6017.

Hamad Alshetaiwi, Nicholas Pervolarakis, Laura Lynn McIntyre ... Anushka Silva, Craig Walsh, Kai Kessenbrock

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Cancer BiologyNicholas LiaoOctober 12, 20202020-02 (Feb)
A case report of clonal EBV-like memory CD4 + T cell activation in fatal checkpoint inhibitor-induced encephalitis
A case report of clonal EBV-like memory CD4 + T cell activation in fatal checkpoint inhibitor-induced encephalitis

Nat Med. 2019 Aug;25(8):1243-1250. doi: 10.1038/s41591-019-0523-2.

Douglas B Johnson, Wyatt J McDonnell, Paula I Gonzalez-Ericsson ... Melinda E Sanders, Jeffrey A Sosman, Justin M Balko

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Medicine, Immunology & MicrobiologyNicholas LiaoOctober 9, 20202019-08
Promotion of Axon Growth by the Secreted End of a Transcription Factor
Promotion of Axon Growth by the Secreted End of a Transcription Factor

Cell Rep. 2019 Oct 8;29(2):363-377.e5. doi: 10.1016/j.celrep.2019.08.101.

Ethan P McCurdy, Kyung Min Chung, Carlos R Benitez-Agosto, Ulrich Hengst

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Neuroscience, BiochemistryNicholas LiaoOctober 8, 20202019-10
Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome
Phenotype and kinetics of SARS-CoV-2-specific T cells in COVID-19 patients with acute respiratory distress syndrome

Sci Immunol. 2020 Jun 26;5(48):eabd2071. doi: 10.1126/sciimmunol.abd2071.

Daniela Weiskopf, Katharina S Schmitz, Matthijs P Raadsen ... Rik L de Swart, Alessandro Sette, Rory D de Vries

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Immunology & Microbiology, Medicine, COVID-19Nicholas LiaoOctober 6, 20202020-06
Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

Cancer Cell. 2020 May 11;37(5):720-734.e13. doi: 10.1016/j.ccell.2020.04.002.

Pavlos Msaouel, Gabriel G Malouf, Xiaoping Su ... Cheryl L Walker, Giannicola Genovese, Nizar M Tannir

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Cancer BiologyNicholas LiaoOctober 5, 20202020-05
CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response
CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response

Nat Genet. 2020 Jul;52(7):655-661. doi: 10.1038/s41588-020-0643-0.

Grégoire Stik, Enrique Vidal, Mercedes Barrero ... Marc A Marti-Renom, Ralph Stadhouders, Thomas Graf

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Genomics, Immunology & Microbiology, Genetics & Genome BiologyNicholas LiaoOctober 1, 20202020-07 (Jul)
Ahr-Foxp3-RORγt axis controls gut homing of CD4 + T cells by regulating GPR15
Ahr-Foxp3-RORγt axis controls gut homing of CD4 + T cells by regulating GPR15

Sci Immunol. 2020 Jun 12;5(48):eaaz7277. doi: 10.1126/sciimmunol.aaz7277.

Lifeng Xiong, Joseph W Dean, Zheng Fu ... Zongming E Chen, Marcus Mühlbauer, Liang Zhou

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Immunology & Microbiology, BiochemistryNicholas LiaoSeptember 30, 2020
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Cell Metab. 2020 Sep 1;32(3):468-478.e7. doi: 10.1016/j.cmet.2020.07.016.

Alexander Hooftman, Stefano Angiari, Svenja Hester ... Alan D Irvine, Roman Fischer, Luke A J O'Neill

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Immunology & MicrobiologyNicholas LiaoSeptember 28, 20202020-09 (Sep)
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing
Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing

Cell Stem Cell. 2020 Sep 3;27(3):396-412.e6. doi: 10.1016/j.stem.2020.07.008.

Sepideh Abbasi, Sarthak Sinha, Elodie Labit ... Fabio M V Rossi, T Michael Underhill, Jeff Biernaskie

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Cell & Developmental BioNicholas LiaoSeptember 24, 20202020-09 (Sep)
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