Cas9 activates the p53 pathway and selects for p53-inactivating mutations

Nat Genet. 2020 Jul;52(7):662-668. doi: 10.1038/s41588-020-0623-4.

Oana M Enache, Veronica Rendo, Mai Abdusamad ... Rameen Beroukhim, Todd R Golub, Uri Ben-David

Genetics & Genome Biology, GenomicsNicholas LiaoSeptember 23, 20202020-07 (Jul)

Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice

Nat Neurosci. 2020 Sep;23(9):1090-1101. doi: 10.1038/s41593-020-0663-1.

Julie Ouellette, Xavier Toussay, Cesar H Comin ... Dylan Burger, Duncan J Stewart, Baptiste Lacoste

NeuroscienceNicholas LiaoSeptember 21, 20202020-09 (Sep)

Seminar: Deconstructing Breast Cancer Using a Developmental Perspective

Cell Rep. 2019 | PubMed

Cell Rep. 2018 | PubMed

Cancer Cell. 2018 | PubMed

Cancer Biology, SeminarsNicholas LiaoSeptember 18, 20202019-10 (Oct)

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

Cell Stem Cell. 2020 Aug 14;S1934-5909(20)30359-3. doi: 10.1016/j.stem.2020.07.021.

Courtney L Jones, Brett M Stevens, Daniel A Pollyea ... Clayton A Smith, Angelo D'Alessandro, Craig T Jordan

Cell & Developmental Bio, Cancer Biology, MetabolismNicholas LiaoSeptember 17, 20202020-08 (Aug)

PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression

Cancer Cell. 2020 Aug 10;38(2):247-262.e11. doi: 10.1016/j.ccell.2020.05.018.

Yotaro Kudo, Masayuki Sugimoto, Esperanza Arias ... Michael Karin, Maria T Diaz-Meco, Jorge Moscat

Cancer BiologyNicholas LiaoSeptember 15, 20202020-08 (Aug)

Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

Nat Neurosci. 2020 Jul;23(7):842-853. doi: 10.1038/s41593-020-0628-4.

Alexandra Garancher, Hiromichi Suzuki, Svasti Haricharan ... Carl F Ware, Michael D Taylor, Robert J Wechsler-Reya

Cancer Biology, Immunology & MicrobiologyNicholas LiaoSeptember 10, 20202020-07 (Jul)

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

Cell Rep. 2019 Dec 10;29(11):3405-3420.e5. doi: 10.1016/j.celrep.2019.11.008.

William W Feng, Owen Wilkins, Scott Bang ... Chao Cheng, William B Kinlaw, Manabu Kurokawa

Cancer Biology, MetabolismNicholas LiaoSeptember 8, 20202019-12 (Dec)

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Sci Transl Med. 2019 Sep 18;11(510):eaav5055. doi: 10.1126/scitranslmed.aav5055.

Ioannis Akoumianakis, Fabio Sanna, Marios Margaritis ... Dimitris Tousoulis, Keith M Channon, Charalambos Antoniades

Metabolism, MedicineNicholas LiaoSeptember 4, 20202019-09 (Sep)

Adipocyte Fatty Acid Transfer Supports Megakaryocyte Maturation

Cell Rep. 2020 Jul 7;32(1):107875. doi: 10.1016/j.celrep.2020.107875.

Colin Valet, Aurelie Batut, Alicia Vauclard ... Bernard Payrastre, Philippe Valet, Sonia Severin

Cell & Developmental BioNicholas LiaoSeptember 2, 20202020-07 (Jul)

Integrins Modulate Extracellular Matrix Organization to Control Cell Signaling during Hematopoiesis

Curr Biol. 2020 Jul 4;S0960-9822(20)30843-5. doi: 10.1016/j.cub.2020.06.027.

Rohan J Khadilkar, Kevin Y L Ho, Bhavya Venkatesh, Guy Tanentzapf

Cell & Developmental BioNicholas LiaoAugust 31, 20202020-07 (Jul)

USP22 controls multiple signaling pathways that are essential for vasculature formation in the mouse placenta

Development. 2019 Feb 22;146(4):dev174037. doi: 10.1242/dev.174037.

Evangelia Koutelou, Li Wang, Andria C Schibler ... Boyko S Atanassov, Dean G Tang, Sharon Y R Dent

Cell & Developmental BioNicholas LiaoAugust 27, 20202019-02 (Feb)

Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss

Cell. 2020 Jan 9;180(1):64-78.e16. doi: 10.1016/j.cell.2019.12.002.

Fanny Matheis, Paul A Muller, Christina L Graves ... Tomasz Ahrends, Philip Rosenstiel, Daniel Mucida

Immunology & Microbiology, NeuroscienceNicholas LiaoAugust 26, 20202020-01 (Jan)

Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

Cell Metab. 2019 Jan 8;29(1):192-201.e7. doi: 10.1016/j.cmet.2018.08.013.

Sung Min Son, So Jung Park, Huikyong Lee ... Jong Eun Lee, Fiona M Menzies, David C Rubinsztein

Metabolism, BiochemistryNicholas LiaoAugust 24, 20202019-01 (Jan)

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

Nat Commun. 2020 Jun 19;11(1):3150. doi: 10.1038/s41467-020-16819-z.

Joanne M Hildebrand, Maria Kauppi, Ian J Majewski ... James M Murphy, Warren S Alexander, John Silke

Cell & Developmental Bio, Biochemistry, MedicineNicholas LiaoAugust 20, 20202020-06 (Jun)

MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis

Nat Commun. 2020 Jun 19;11(1):3151. doi: 10.1038/s41467-020-16887-1.

Andre L Samson, Ying Zhang, Niall D Geoghegan ... Guillaume Lessene, Edwin D Hawkins, James M Murphy

Cell & Developmental Bio, BiochemistryNicholas LiaoAugust 19, 20202020-06 (Jun)

Paroxysmal slow cortical activity in Alzheimer's disease and epilepsy is associated with blood-brain barrier dysfunction

Sci Transl Med. 2019 Dec 4;11(521):eaaw8954. doi: 10.1126/scitranslmed.aaw8954.

Dan Z Milikovsky, Jonathan Ofer, Vladimir V Senatorov Jr ... Felix Benninger, Daniela Kaufer, Alon Friedman

Neuroscience, MedicineNicholas LiaoAugust 17, 20202019-12 (Dec)

GWAS for Lifespan and Decline in Climbing Ability in Flies upon Dietary Restriction Reveal decima as a Mediator of Insulin-like Peptide Production

Curr Biol. 2020 Jul 20;30(14):2749-2760.e3. doi: 10.1016/j.cub.2020.05.020.

Kenneth A Wilson, Jennifer N Beck, Christopher S Nelson ... Daniel Promislow, Rachel B Brem, Pankaj Kapa

MetabolismNicholas LiaoAugust 13, 20202020-07 (Jul)

Post-translational Modification of OTULIN Regulates Ubiquitin Dynamics and Cell Death

Cell Rep. 2019 Dec 10;29(11):3652-3663.e5. doi: 10.1016/j.celrep.2019.11.014.

Todd Douglas, Maya Saleh

BiochemistryNicholas LiaoAugust 12, 20202019-12 (Dec)