Automated design of thousands of nonrepetitive parts for engineering stable genetic systems

Nat Biotechnol. 2020 Dec;38(12):1466-1475. doi: 10.1038/s41587-020-0584-2.

Ayaan Hossain, Eriberto Lopez, Sean M Halper ... Devin Strickland, Eric Klavins, Howard M Salis

Biotechnology, Genetics & Genome BiologyNicholas LiaoDecember 9, 20202020-12 (Dec)

TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate

Cell. 2020 Jul 23;182(2):297-316.e27. doi: 10.1016/j.cell.2020.05.049.

Leandro Venturutti, Matt Teater, Andrew Zhai ... David W Scott, Gilbert G Privé, Ari M Melnick

Cancer BiologyNicholas LiaoDecember 7, 20202020-07 (Jul)

Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19

Nat Immunol. 2020 Dec;21(12):1506-1516. doi: 10.1038/s41590-020-00814-z.

Matthew C Woodruff, Richard P Ramonell, Doan C Nguyen ... William T Hu, F Eun-Hyung Lee, Ignacio Sanz

COVID-19, Immunology & Microbiology, MedicineNicholas LiaoDecember 4, 20202020-12 (Dec)

ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition

Cell Rep. 2020 Sep 1;32(9):108096. doi: 10.1016/j.celrep.2020.108096.

Michael D Rainey, Declan Bennett, Rachel O'Dea ... Muriel Voisin, Cathal Seoighe, Corrado Santocanale

Biochemistry, Cell & Developmental BioNicholas LiaoDecember 3, 20202020-09 (Sep)

CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage

EMBO Rep. 2020 Aug 5;21(8):e48920. doi: 10.15252/embr.201948920.

Michael D Rainey, Aisling Quinlan, Chiara Cazzaniga ... Anja Göder, Massimo Lopes, Corrado Santocanale

Biochemistry, Cancer BiologyNicholas LiaoDecember 1, 20202020-08 (Aug)

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

Cell. 2020 Oct 29;183(3):818-834.e13. doi: 10.1016/j.cell.2020.09.015.

Daniel K Wells, Marit M van Buuren, Kristen K Dang ... Ton N Schumacher, Pia Kvistborg, Nadine A Defranoux

Cancer Biology, MedicineNicholas LiaoNovember 30, 20202020-10 (Oct)

Two subsets of stem-like CD8 + memory T cell progenitors with distinct fate commitments in humans

Nat Immunol. 2020 Dec;21(12):1552-1562. doi: 10.1038/s41590-020-0791-5.

Giovanni Galletti, Gabriele De Simone, Emilia M C Mazza ... Evan W Newell, Monica Casucci, Enrico Lugli

Immunology & MicrobiologyNicholas LiaoNovember 25, 20202020--12 (Dec)

Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

Cell. 2020 Aug 6;182(3):641-654.e20. doi: 10.1016/j.cell.2020.06.014.

Lin Wu, Kate E R Hollinshead, Yuhan Hao ... Alec C Kimmelman, Rahul Satija, Dan R Littman

Metabolism, Immunology & MicrobiologyNicholas LiaoNovember 24, 20202020-08 (Aug)

TREML4 receptor regulates inflammation and innate immune cell death during polymicrobial sepsis

Nat Immunol. 2020 Dec;21(12):1585-1596. doi: 10.1038/s41590-020-0789-z.

Christina Nedeva, Joseph Menassa, Mubing Duan ... Weisan Chen, Mark D Hulett, Hamsa Puthalakath

Immunology & MicrobiologyNicholas LiaoNovember 23, 20202020-10 (Oct)

Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I interferon production

J Clin Invest. 2020 Sep 29;136824. doi: 10.1172/JCI136824.

Line S Reinert, Ahmad S Rashidi, Diana N Tran ... Henrik Zetterberg, Georges Mgm Verjans, Soren R Paluden

Immunology & MicrobiologyNicholas LiaoNovember 20, 20202020-09 (Sep)

TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

Cell. 2020 Oct 29;183(3):636-649.e18. doi: 10.1016/j.cell.2020.09.020.

Chien-Hsiung Yu, Sophia Davidson, Cassandra R Harapas ... Kate McArthur, Peter J Crouch, Seth L Masters

Neuroscience, Immunology & Microbiology, MedicineNicholas LiaoNovember 19, 20202020-10 (Oct)

Activate: Randomized Clinical Trial of BCG Vaccination against Infection in the Elderly

Cell. 2020 Oct 15;183(2):315-323.e9. doi: 10.1016/j.cell.2020.08.051.

Evangelos J Giamarellos-Bourboulis, Maria Tsilika, Simone Moorlag ... George Renieris, Antonios Papadopoulos, Mihai G Netea

Immunology & Microbiology, MedicineNicholas LiaoNovember 17, 20202020-10 (Oct)

Mutations disrupting neuritogenesis genes confer risk for cerebral palsy

Nat Genet. 2020 Oct;52(10):1046-1056. doi: 10.1038/s41588-020-0695-1.

Sheng Chih Jin, Sara A Lewis, Somayeh Bakhtiari ... Jozef Gecz, Alastair H MacLennan, Michael C Kruer

Neuroscience, Cell & Developmental BioNicholas LiaoNovember 16, 20202020-10 (Oct)

Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells

Nat Immunol. 2020 Nov 2. doi: 10.1038/s41590-020-00810-3.

Faezzah Baharom, Ramiro A Ramirez-Valdez, Kennedy K S Tobin ... Florent Ginhoux, Andrew S Ishizuka, Robert A Seder

Immunology & Microbiology, Cancer BiologyNicholas LiaoNovember 13, 20202020-11 (Nov)

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

Cell. 2020 Sep 17;182(6):1531-1544.e15. doi: 10.1016/j.cell.2020.07.043.

Jason Z Zhang, Tsan-Wen Lu, Lucas M Stolerman ... Susan S Taylor, Sohum Mehta, Jin Zhang

Cancer Biology, BiochemistryNicholas LiaoNovember 12, 20202020-09 (Sep)

A genetic mechanism for sexual dichromatism in birds

Science. 2020 Jun 12;368(6496):1270-1274. doi: 10.1126/science.aba0803.

Małgorzata A Gazda, Pedro M Araújo, Ricardo J Lopes ... Geoffrey E Hill, Joseph C Corbo, Miguel Carneiro

Genetics & Genome BiologyNicholas LiaoNovember 10, 20202020-06 (Jun)

Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability

Cell Stem Cell. 2020 Feb 6;26(2):221-233.e6. doi: 10.1016/j.stem.2019.12.013.

Meiyan Wang, Pei-Chi Wei, Christina K Lim ... Maria C Marchetto, Frederick W Alt, Fred H Gage

Neuroscience, Cell & Developmental BioNicholas LiaoNovember 5, 20202020-02 (Feb)

A mathematical model reveals the influence of population heterogeneity on herd immunity to SARS-CoV-2

Science. 2020 Aug 14;369(6505):846-849. doi: 10.1126/science.abc6810.

Tom Britton, Frank Ball, Pieter Trapman

Immunology & Microbiology, COVID-19Nicholas LiaoNovember 3, 20202020-08 (Aug)