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Research Films RSS
Screen Shot 2019-08-28 at 10.03.25 PM.png
Open-channel metal particle superlattices
Open-channel metal particle superlattices

Nature. 2022 Nov;611(7937):695-701. doi: 10.1038/s41586-022-05291-y.

Yuanwei Li, Wenjie Zhou, Ibrahim Tanriover ... Vinayak P Dravid, Koray Aydin, Chad A Mirkin

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Biotechnology, Physical Sciences, BiochemistryNicholas LiaoApril 12, 20232022-11 (Nov)
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation

Nat Immunol. 2022 May;23(5):692-704. doi: 10.1038/s41590-022-01185-3.

Leah K Billingham, Joshua S Stoolman, Karthik Vasan ... Peng Zhang, Jason Miska, Navdeep S Chandel

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Metabolism, Immunology & MicrobiologyNicholas LiaoMarch 9, 20232022-05 (May)
Non-canonical β-adrenergic activation of ERK at endosomes
Non-canonical β-adrenergic activation of ERK at endosomes

Nature. 2022 Nov;611(7934):173-179. doi: 10.1038/s41586-022-05343-3.

Yonghoon Kwon, Sohum Mehta, Mary Clark ... Ha Neul Lee, Roger K Sunahara, Jin Zhang

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BiochemistryNicholas LiaoMarch 7, 20232022-11 (Nov)
Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy
Rebalancing TGFβ1/BMP signals in exhausted T cells unlocks responsiveness to immune checkpoint blockade therapy

Nat Immunol. 2023 Feb;24(2):280-294. doi: 10.1038/s41590-022-01384-y.

Abbey A Saadey, Amir Yousif, Nicole Osborne ... Parker Bauman, Amy Webb, Hazem E Ghoneim

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Cancer Biology, Immunology & MicrobiologyNicholas LiaoFebruary 23, 20232023-02 (Feb)
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis
Dissecting the treatment-naive ecosystem of human melanoma brain metastasis

Cell. 2022 Jul 7;185(14):2591-2608.e30. doi: 10.1016/j.cell.2022.06.007.

Jana Biermann, Johannes C Melms, Amit Dipak Amin ... Fei Chen, Gary K Schwartz, Benjamin Izar

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Cancer BiologyNicholas LiaoFebruary 21, 20232022-07 (Jul)
Antibody targeting of E3 ubiquitin ligases for receptor degradation
Antibody targeting of E3 ubiquitin ligases for receptor degradation

Nature. 2022 Oct;610(7930):182-189. doi: 10.1038/s41586-022-05235-6.

Hadir Marei, Wen-Ting K Tsai, Yee-Seir Kee ... Jing Li, Nicholas J Agard, Felipe de Sousa E Melo

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Biotechnology, Cancer Biology, BiochemistryNicholas LiaoFebruary 14, 20232022-10 (Oct)
Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction
Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction

Nature. 2022 Jul;607(7920):762-768. doi: 10.1038/s41586-022-04916-6.

Sung-Wook Hong, Peter D Krueger, Kevin C Osum ... Adam Herman, Daniel L Mueller, Marc K Jenkins

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Immunology & MicrobiologyNicholas LiaoFebruary 11, 20232022-07 (Jul)
Mitochondrial base editor induces substantial nuclear off-target mutations
Mitochondrial base editor induces substantial nuclear off-target mutations

Nature. 2022 Jun;606(7915):804-811. doi: 10.1038/s41586-022-04836-5.

Zhixin Lei, Haowei Meng, Lulu Liu ... Min Liu, Aibin He, Chengqi Yi

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Biotechnology, Genetics & Genome BiologyNicholas LiaoFebruary 2, 20232022-06 (Jun)
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL
Non-viral, specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

Nature. 2022 Sep;609(7926):369-374. doi: 10.1038/s41586-022-05140-y.

Jiqin Zhang, Yongxian Hu, Jiaxuan Yang ... Bing Du, Mingyao Liu, He Huang

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Biotechnology, Cancer Biology, Immunology & MicrobiologyNicholas LiaoJanuary 10, 20232022-09 (Sep)
Bending forces and nucleotide state jointly regulate F-actin structure
Bending forces and nucleotide state jointly regulate F-actin structure

Nature. 2022 Nov;611(7935):380-386. doi: 10.1038/s41586-022-05366-w.

Matthew J Reynolds, Carla Hachicho, Ayala G Carl, Rui Gong, Gregory M Alushin

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Biochemistry, Structural BiologyNicholas LiaoJanuary 6, 20232022-11 (Nov)
Shape memory in self-adapting colloidal crystals
Shape memory in self-adapting colloidal crystals

Nature. 2022 Oct;610(7933):674-679. doi: 10.1038/s41586-022-05232-9.

Seungkyu Lee, Heather A Calcaterra, Sangmin Lee ... Koray Aydin, Sharon C Glotzer, Chad A Mirkin

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Physical SciencesNicholas LiaoJanuary 3, 20232022-10 (Oct)
A B1a-natural IgG-neutrophil axis is impaired in viral- and steroid-associated aspergillosis
A B1a-natural IgG-neutrophil axis is impaired in viral- and steroid-associated aspergillosis

Sci Transl Med. 2022 Dec 7;14(674):eabq6682. doi: 10.1126/scitranslmed.abq6682.

Nicole Sarden, Sarthak Sinha, Kyle G Potts ... Nicole Rosin, Jeff Biernaskie, Bryan G Yipp

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Immunology & MicrobiologyNicholas LiaoDecember 21, 20222022-12 (Dec)
Phenotypic plasticity and genetic control in colorectal cancer evolution
Phenotypic plasticity and genetic control in colorectal cancer evolution

Nature. 2022 Nov;611(7937):744-753. doi: 10.1038/s41586-022-05311-x.

Jacob Househam, Timon Heide, George D Cresswell ... Luca Magnani, Andrea Sottoriva, Trevor A Graham

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Genomics, Cancer BiologyNicholas LiaoDecember 13, 20222022-11 (Nov)
Molecular Programs Driving Skin Regeneration and Scarring at Single-cell Resolution
Molecular Programs Driving Skin Regeneration and Scarring at Single-cell Resolution

Recently accepted in Cell

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Seminars, Immunology & Microbiology, Cell & Developmental BioNicholas LiaoDecember 8, 20222022-12 (Dec)
Screening for generality in asymmetric catalysis
Screening for generality in asymmetric catalysis

Nature. 2022 Oct;610(7933):680-686. doi: 10.1038/s41586-022-05263-2.

Corin C Wagen, Spencer E McMinn, Eugene E Kwan, Eric N Jacobsen

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Biotechnology, BiochemistryNicholas LiaoDecember 1, 20222022-10 (Oct)
The evolution and diversification of oakleaf butterflies
The evolution and diversification of oakleaf butterflies

Cell. 2022 Aug 18;185(17):3138-3152.e20. doi: 10.1016/j.cell.2022.06.042.

Shuting Wang, Dequn Teng, Xueyan Li ... Li Zhang, Wen Wang, Wei Zhang

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Genetics & Genome BiologyNicholas LiaoNovember 29, 20222022-08 (Aug)
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

Cell. 2022 May 26;185(11):1924-1942.e23. doi: 10.1016/j.cell.2022.04.019.

Nathan E Reticker-Flynn, Weiruo Zhang, Julia A Belk ... Ansuman T Satpathy, Sylvia K Plevritis, Edgar G Engleman

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Cancer Biology, Immunology & MicrobiologyNicholas LiaoNovember 17, 20222022-05 (May)
Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome
Spindle-shaped archaeal viruses evolved from rod-shaped ancestors to package a larger genome

Cell. 2022 Apr 14;185(8):1297-1307.e11. doi: 10.1016/j.cell.2022.02.019.

Fengbin Wang, Virginija Cvirkaite-Krupovic, Matthijn Vos ... Stefan Schouten, Mart Krupovic, Edward H Egelman

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MicrobiologyNicholas LiaoNovember 15, 20222022-04 (Apr)
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