Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA

Nat Med. 2022 May;28(5):946-957. doi: 10.1038/s41591-022-01786-3.

Smita S Chandran, Jiaqi Ma, Martin G Klatt ... David A Scheinberg, Brian M Baker, Christopher A Klebanoff

Cancer Biology, Immunology & Microbiology, MedicineNicholas LiaoNovember 3, 20222022-05 (May)

A segmentation clock patterns cellular differentiation in a bacterial biofilm

Cell. 2022 Jan 6;185(1):145-157.e13. doi: 10.1016/j.cell.2021.12.001.

Kwang-Tao Chou, Dong-Yeon D Lee, Jian-Geng Chiou ... San Ly, Jordi Garcia-Ojalvo, Gürol M Süel

MicrobiologyNicholas LiaoNovember 1, 20222022-01 (Jan)

SnapHiC: a computational pipeline to identify chromatin loops from single-cell Hi-C data

Nat Methods. 2021 Sep;18(9):1056-1059. doi: 10.1038/s41592-021-01231-2.

Miao Yu, Armen Abnousi, Yanxiao Zhang ... Yun Li, Bing Ren, Ming Hu

Genetics & Genome Biology, BiotechnologyNicholas LiaoOctober 27, 20222021-09 (Sep)

Experimental reproducibility limits the correlation between mRNA and protein abundances in tumor proteomic profiles

Cell Rep Methods. 2022 Sep 8;2(9):100288. doi: 10.1016/j.crmeth.2022.100288.

Swathi Ramachandra Upadhya, Colm J Ryan

Biotechnology, Genetics & Genome Biology, Cancer BiologyNicholas LiaoOctober 25, 20222022-09 (Sep)

A T cell resilience model associated with response to immunotherapy in multiple tumor types

Nat Med. 2022 Jul;28(7):1421-1431. doi: 10.1038/s41591-022-01799-y.

Yu Zhang, Trang Vu, Douglas C Palmer ... Kenneth Aldape, Xin-Yuan Guan, Peng Jiang

Cancer Biology, Immunology & MicrobiologyNicholas LiaoOctober 13, 20222022-05

Amplification of human interneuron progenitors promotes brain tumors and neurological defects

Science. 2022 Jan 28;375(6579):eabf5546. doi: 10.1126/science.abf5546.

Oliver L Eichmüller, Nina S Corsini, Ábel Vértesy ... Mercedes F Paredes, Martha Feucht, Jürgen A Knoblich

NeuroscienceNicholas LiaoOctober 11, 20222022-01 (Jan)

Molecular and functional architecture of striatal dopamine release sites

Neuron. 2022 Jan 19;110(2):248-265.e9. doi: 10.1016/j.neuron.2021.10.028.

Aditi Banerjee, Cordelia Imig, Karthik Balakrishnan ... Sonja M Wojcik, Nils Brose, Pascal S Kaeser

NeuroscienceNicholas LiaoOctober 6, 20222022-01 (Jan)

Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

Nat Med. 2022 Apr;28(4):752-765. doi: 10.1038/s41591-022-01749-8.

Cátia Monteiro, Lauritz Miarka, María Perea-García ... Neta Erez, RENACER, Manuel Valiente

Cancer Biology, MedicineNicholas LiaoOctober 4, 20222022-04 (Apr)

Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy

Nat Med. 2022 Mar;28(3):557-567. doi: 10.1038/s41591-022-01696-4.

Irene Ganan-Gomez, Hui Yang, Feiyang Ma ... Karen Clise-Dwyer, Guillermo Garcia-Manero, Simona Colla

Cancer Biology, Cell & Developmental BioNicholas LiaoSeptember 29, 20222022-03 (Mar)

Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

Cell Stem Cell. 2022 Mar 3;29(3):355-371.e10. doi: 10.1016/j.stem.2022.02.006.

John M Hallett, Sofia Ferreira-Gonzalez, Tak Yung Man ... David C Hay, Anthony Callanan, Stuart J Forbes

Cell & Developmental BioNicholas LiaoSeptember 27, 20222022-03 (Mar)

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection

Nat Biotechnol. 2021 Aug;39(8):928-935. doi: 10.1038/s41587-021-00878-8.

Susanna K Elledge, Xin X Zhou, James R Byrnes ... Kevin K Leung, Bryan Greenhouse, James A Wells

Biotechnology, Medicine, Immunology & MicrobiologyNicholas LiaoSeptember 15, 20222021-08 (Aug)

Mass photometry enables label-free tracking and mass measurement of single proteins on lipid bilayers

Nat Methods. 2021 Oct;18(10):1247-1252. doi: 10.1038/s41592-021-01261-w.

Eric D B Foley, Manish S Kushwah, Gavin Young, Philipp Kukura

Biochemistry, BiotechnologyNicholas LiaoSeptember 13, 20222021-10 (Oct)

Fast optical recording of neuronal activity by three-dimensional custom-access serial holography

Nat Methods. 2022 Jan;19(1):100-110. doi: 10.1038/s41592-021-01329-7.

Walther Akemann, Sébastien Wolf, Vincent Villette ... Jean-François Léger, Stéphane Dieudonné, Laurent Bourdieu

Biotechnology, NeuroscienceNicholas LiaoAugust 25, 20222022-01 (Jan)

Organoid modeling of Zika and herpes simplex virus 1 infections reveals virus-specific responses leading to microcephaly

Cell Stem Cell. 2021 Aug 5;28(8):1362-1379.e7. doi: 10.1016/j.stem.2021.03.004.

Veronica Krenn, Camilla Bosone, Thomas R Burkard ... Patricia Pestana Garcez, Ali Mirazimi, Jürgen A Knoblich

Immunology & MicrobiologyNicholas LiaoAugust 23, 20222021-08 (Aug)

APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function

Sci Transl Med. 2021 Feb 17;13(581):eabd7522. doi: 10.1126/scitranslmed.abd7522.

Monica Xiong, Hong Jiang, Javier Remolina Serrano ... Jason D Ulrich, Gregory J Zipfel, David M Holtzman

NeuroscienceNicholas LiaoAugust 11, 20222021-02 (Feb)

Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism

Sci Transl Med. 2021 May 19;13(594):eaaw1564. doi: 10.1126/scitranslmed.aaw1564.

Joanne Ng, Serena Barral, Carmen De La Fuente Barrigon ... Maximilien Bencze, Simon N Waddington, Manju A Kurian

Biotechnology, Medicine, NeuroscienceNicholas LiaoAugust 9, 20222021-05 (May)

Spectral entropy outperforms MS/MS dot product similarity for small-molecule compound identification

Nat Methods. 2021 Dec;18(12):1524-1531. doi: 10.1038/s41592-021-01331-z.

Yuanyue Li, Tobias Kind, Jacob Folz, Arpana Vaniya, Sajjan Singh Mehta, Oliver Fiehn

Biotechnology, BiochemistryNicholas LiaoJuly 28, 20222021-12 (Dec)

Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma

Immunity. 2021 Aug 10;54(8):1825-1840.e7. doi: 10.1016/j.immuni.2021.06.013.

Yang Cheng, Bavani Gunasegaran, Harsimran D Singh ... Weiwei Zhai, Su Pin Choo, Evan W Newell

Cancer Biology, Immunology & MicrobiologyNicholas LiaoJuly 26, 20222021-08 (Aug)