Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation

Cell Metab. 2020 Jul 7;32(1):44-55.e6. doi: 10.1016/j.cmet.2020.04.015.

Leena P Bharath, Madhur Agrawal, Grace McCambridge ... Elizabeth A Proctor, Philip A Kern, Barbara S Nikolajczyk

Immunology & Microbiology, MetabolismNicholas LiaoJune 3, 20212020-07 (Jul)

Calmodulin inhibitors improve erythropoiesis in Diamond-Blackfan anemia

Sci Transl Med. 2020 Oct 21;12(566):eabb5831. doi: 10.1126/scitranslmed.abb5831.

Alison M Taylor, Elizabeth R Macari, Iris T Chan ... Yi Zhou, George Q Daley, Leonard I Zon

Cell & Developmental Bio, MedicineNicholas LiaoJune 1, 20212020-10 (Oct)

Deep learning suggests that gene expression is encoded in all parts of a co-evolving interacting gene regulatory structure

Nat Commun. 2020 Dec 1;11(1):6141. doi: 10.1038/s41467-020-19921-4.

Jan Zrimec, Christoph S Börlin, Filip Buric ... Jens Nielsen, Mats Töpel, Aleksej Zelezniak

Biochemistry, Genetics & Genome BiologyNicholas LiaoMay 27, 20212020-12 (Dec)

Kethoxal-assisted single-stranded DNA sequencing captures global transcription dynamics and enhancer activity in situ

Nat Methods. 2020 May;17(5):515-523. doi: 10.1038/s41592-020-0797-9.

Tong Wu, Ruitu Lyu, Qiancheng You, Chuan He

Genomics, Biotechnology, BiochemistryNicholas LiaoMay 24, 20212020-05 (May)

Small-molecule-induced polymerization triggers degradation of BCL6

Nature. 2020 Dec;588(7836):164-168. doi: 10.1038/s41586-020-2925-1.

Mikołaj Słabicki, Hojong Yoon, Jonas Koeppel ... Radosław P Nowak, Eric S Fischer, Benjamin L Ebert

BiochemistryNicholas LiaoMay 20, 20212020-12 (Dec)

CRISPR-assisted detection of RNA-protein interactions in living cells

Nat Methods. 2020 Jul;17(7):685-688. doi: 10.1038/s41592-020-0866-0.

Wenkai Yi, Jingyu Li, Xiaoxuan Zhu ... Kui Ming Chan, Liang Zhang, Jian Yan

GenomicsNicholas LiaoMay 18, 20212020-07 (Jul)

Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy

Nat Commun. 2020 Dec 17;11(1):6410. doi: 10.1038/s41467-020-19917-0.

Amy J Wisdom, Yvonne M Mowery, Cierra S Hong ... Maximilian Diehn, Todd Bradley, David G Kirsch

Cancer Biology, GenomicsNicholas LiaoMay 13, 20212020-12 (Dec)

The iron-dependent repressor YtgR is a tryptophan-dependent attenuator of the trpRBA operon in Chlamydia trachomatis

Nat Commun. 2020 Dec 22;11(1):6430. doi: 10.1038/s41467-020-20181-5.

Nick D Pokorzynski, Nathan D Hatch, Scot P Ouellette, Rey A Carabeo

Cell & Developmental BioNicholas LiaoMay 11, 20212020-12 (Dec)

Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact

Cell. 2020 Nov 25;183(5):1185-1201.e20. doi: 10.1016/j.cell.2020.11.002.

Willian A da Silveira, Hossein Fazelinia, Sara Brin Rosenthal ... Christopher E Mason, Sylvain V Costes, Afshin Beheshti

Cell & Developmental Bio, Genomics, Metabolism, MedicineNicholas LiaoMay 6, 20212020-11 (Nov)

Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

Cancer Cell. 2021 Feb 8;39(2):193-208.e10. doi: 10.1016/j.ccell.2020.11.005.

Shivani Srivastava, Scott N Furlan, Carla A Jaeger-Ruckstuhl ... Raphael Gottardo, David G Maloney, Stanley R Riddell

Cancer Biology, Immunology & Microbiology, MedicineNicholas LiaoMay 4, 20212021-02 (Feb)

CD40 Agonist Overcomes T Cell Exhaustion Induced by Chronic Myeloid Cell IL-27 Production in a Pancreatic Cancer Preclinical Model

J Immunol. 2021 Mar 15;206(6):1372-1384. doi: 10.4049/jimmunol.2000765.

Adam L Burrack, Meagan R Rollins, Ellen J Spartz ... Iris X Wang, Ross M Kedl, Ingunn M Stromnes

Cancer Biology, Immunology & MicrobiologyNicholas LiaoApril 29, 20212021-03 (Mar)

Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

Cell. 2020 Dec 10;183(6):1617-1633.e22. doi: 10.1016/j.cell.2020.11.012.

Carol C L Chen, Shriya Deshmukh, Selin Jessa ... Paolo Salomoni, Claudia L Kleinman, Nada Jabado

Medicine, Cancer Biology, Genetics & Genome BiologyNicholas LiaoApril 27, 20212020-12 (Dec)

Extremely potent human monoclonal antibodies from COVID-19 convalescent patients

Cell. 2021 Apr 1;184(7):1821-1835.e16. doi: 10.1016/j.cell.2021.02.035.

Emanuele Andreano, Emanuele Nicastri, Ida Paciello ... Claudia Sala, Giuseppe Ippolito, Rino Rappuoli

COVID-19, Immunology & Microbiology, MedicineNicholas LiaoApril 22, 20212021-04 (Apr)

Interleukin-2 signals converge in a lymphoid-dendritic cell pathway that promotes anticancer immunity

Sci Transl Med. 2020 Sep 16;12(561):eaba5464. doi: 10.1126/scitranslmed.aba5464.

Miro E Raeber, Rodney A Rosalia, Dominic Schmid, Ufuk Karakus, Onur Boyman

Cancer Biology, Immunology & MicrobiologyNicholas LiaoApril 20, 20212020-09 (Sep)

Generation of Functional Organs Using a Cell-Competitive Niche in Intra- and Inter-species Rodent Chimeras

Cell Stem Cell. 2021 Jan 7;28(1):141-149.e3. doi: 10.1016/j.stem.2020.11.019.

Toshiya Nishimura, Fabian P Suchy, Joydeep Bhadury, Kyomi J Igarashi, Carsten T Charlesworth, Hiromitsu Nakauchi

Cell & Developmental BioNicholas LiaoApril 15, 20212021-01 (Jan)

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

Cell Metab. 2021 Mar 2;33(3):629-648.e10. doi: 10.1016/j.cmet.2020.12.003.

Ahmad A Cluntun, Rachit Badolia, Sandra Lettlova ... Stephen H McKellar, Jared Rutter, Stavros G Drakos

Biochemistry, MetabolismNicholas LiaoApril 13, 20212021-03 (Mar)

An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease

Sci Transl Med. 2020 Dec 9;12(573):eabb1206. doi: 10.1126/scitranslmed.abb1206.

Anamitra Ghosh, Michele M Comerota, Debin Wan ... Sung Hee Hwang, Bruce D Hammock, Hui Zheng

Neuroscience, Biochemistry, MedicineNicholas LiaoApril 8, 20212020-12 (Dec)

Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment

Cell. 2020 Sep 17;182(6):1419-1440.e23. doi: 10.1016/j.cell.2020.08.001.

Jonas Schulte-Schrepping, Nico Reusch, Daniela Paclik ... Antoine-Emmanuel Saliba, Leif Erik Sander, Deutsche COVID-19 OMICS Initiative (DeCOI)

COVID-19, Medicine, Immunology & MicrobiologyNicholas LiaoApril 6, 20212020-09 (Sep)