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Research Films RSS
Screen Shot 2019-08-28 at 10.03.25 PM.png
Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis
Using genetics to prioritize diagnoses for rheumatology outpatients with inflammatory arthritis

Sci Transl Med. 2020 May 27;12(545):eaay1548. doi: 10.1126/scitranslmed.aay1548.

Rachel Knevel, Saskia le Cessie, Chikashi C Terao ... Katherine P Liao, Elizabeth W Karlson, Soumya Raychaudhuri

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Genetics & Genome BiologyNicholas LiaoApril 1, 20212020-05 (May)
Genetic tool development in marine protists: emerging model organisms for experimental cell biology
Genetic tool development in marine protists: emerging model organisms for experimental cell biology

Nat Methods. 2020 May;17(5):481-494. doi: 10.1038/s41592-020-0796-x.

Drahomíra Faktorová, R Ellen R Nisbet, José A Fernández Robledo ... Thomas Mock, Alexandra Z Worden, Julius Lukeš

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Genetics & Genome Biology, BiotechnologyNicholas LiaoMarch 30, 20212020-05 (May)
Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans
Antibody binding to native cytomegalovirus glycoprotein B predicts efficacy of the gB/MF59 vaccine in humans

Sci Transl Med. 2020 Nov 4;12(568):eabb3611. doi: 10.1126/scitranslmed.abb3611.

Jennifer A Jenks, Cody S Nelson, Hunter K Roark ... Zhiqiang An, Cliburn Chan, Sallie R Permar

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Immunology & Microbiology, MedicineNicholas LiaoMarch 25, 20212020-11 (Nov)
B cell acute lymphoblastic leukemia cells mediate RANK-RANKL-dependent bone destruction
B cell acute lymphoblastic leukemia cells mediate RANK-RANKL-dependent bone destruction

Sci Transl Med. 2020 Sep 16;12(561):eaba5942. doi: 10.1126/scitranslmed.aba5942.

Sujeetha A Rajakumar, Eniko Papp, Kathy K Lee ... Johann K Hitzler, Cynthia J Guidos, Jayne S Danska

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Cancer Biology, MedicineNicholas LiaoMarch 23, 20212020-09 (Sep)
Macrophages provide a transient muscle stem cell niche via NAMPT secretion
Macrophages provide a transient muscle stem cell niche via NAMPT secretion

Nature. 2021 Mar;591(7849):281-287. doi: 10.1038/s41586-021-03199-7.

Dhanushika Ratnayake, Phong D Nguyen, Fernando J Rossello ... Mikaël M Martino, Jeroen Bakkers, Peter D Currie

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Cell & Developmental BioNicholas LiaoMarch 18, 20212021-03 (Mar)
Detecting chromatin interactions between and along sister chromatids with SisterC
Detecting chromatin interactions between and along sister chromatids with SisterC

Nat Methods. 2020 Oct;17(10):1002-1009. doi: 10.1038/s41592-020-0930-9.

Marlies E Oomen, Adam K Hedger, Jonathan K Watts, Job Dekker

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GenomicsNicholas LiaoMarch 16, 20212020-10 (Oct)
Identification of the human DPR core promoter element using machine learning
Identification of the human DPR core promoter element using machine learning

Nature. 2020 Sep;585(7825):459-463. doi: 10.1038/s41586-020-2689-7.

Long Vo Ngoc, Cassidy Yunjing Huang, California Jack Cassidy, Claudia Medrano, James T Kadonaga

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Biochemistry, BiotechnologyNicholas LiaoMarch 11, 20212020-09 (Sep)
A systematic evaluation of the design and context dependencies of massively parallel reporter assays
A systematic evaluation of the design and context dependencies of massively parallel reporter assays

Nat Methods. 2020 Nov;17(11):1083-1091. doi: 10.1038/s41592-020-0965-y.

Jason C Klein, Vikram Agarwal, Fumitaka Inoue ... Martin Kircher, Nadav Ahituv, Jay Shendure

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GenomicsNicholas LiaoMarch 9, 20212020-11 (Nov)
ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics
ANXA11 mutations in ALS cause dysregulation of calcium homeostasis and stress granule dynamics

Sci Transl Med. 2020 Oct 21;12(566):eaax3993. doi: 10.1126/scitranslmed.aax3993.

Minyeop Nahm, Su Min Lim, Young-Eun Kim ... Ki-Wook Oh, Chang-Seok Ki, Seung Hyun Kim

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NeuroscienceNicholas LiaoMarch 4, 20212020-10 (Oct)
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19
Prothrombotic autoantibodies in serum from patients hospitalized with COVID-19

Sci Transl Med. 2020 Nov 18;12(570):eabd3876. doi: 10.1126/scitranslmed.abd3876.

Yu Zuo, Shanea K Estes, Ramadan A Ali ... James H Morrissey, Yogendra Kanthi, Jason S Knight

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COVID-19, MedicineNicholas LiaoMarch 2, 20212020-11 (Nov)
Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M
Dectin-1 limits autoimmune neuroinflammation and promotes myeloid cell-astrocyte crosstalk via Card9-independent expression of Oncostatin M

Immunity. 2021 Feb 8;S1074-7613(21)00027-3. doi: 10.1016/j.immuni.2021.01.004.

M Elizabeth Deerhake, Keiko Danzaki, Makoto Inoue ... William E Barclay, Ru-Rong Ji, Mari L Shinohara

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Immunology & Microbiology, NeuroscienceNicholas LiaoFebruary 25, 20212021-02 (Feb)
Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex
Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

Neuron. 2020 Dec 23;108(6):1113-1129.e6. doi: 10.1016/j.neuron.2020.09.034.

Lei Xing, Nereo Kalebic, Takashi Namba, Samir Vaid, Pauline Wimberger, Wieland B Huttner

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NeuroscienceNicholas LiaoFebruary 23, 20212020-12 (Dec)
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment

Cell. 2020 Aug 6;182(3):734-743.e5. doi: 10.1016/j.cell.2020.06.010.

Jing Sun, Zhen Zhuang, Jian Zheng ... Paul B McCray Jr, Stanley Perlman, Jincun Zhao

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COVID-19Nicholas LiaoFebruary 18, 20212020-08 (Aug)
Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport
Local Mitochondrial ATP Production Regulates Endothelial Fatty Acid Uptake and Transport

Cell Metab. 2020 Aug 4;32(2):309-319.e7. doi: 10.1016/j.cmet.2020.05.018.

Ayon Ibrahim, Nora Yucel, Boa Kim, Zoltan Arany

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Cell & Developmental BioNicholas LiaoFebruary 16, 20212020-08 (Aug)
Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes
Sensory Discrimination of Blood and Floral Nectar by Aedes aegypti Mosquitoes

Neuron. 2020 Dec 23;108(6):1163-1180.e12. doi: 10.1016/j.neuron.2020.09.019.

Veronica Jové, Zhongyan Gong, Felix J H Hol ... Manu Prakash, Carolyn S McBride, Leslie B Vosshall

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NeuroscienceNicholas LiaoFebruary 11, 20212020-12 (Dec)
The genomic landscapes of individual melanocytes from human skin
The genomic landscapes of individual melanocytes from human skin

Nature. 2020 Oct;586(7830):600-605. doi: 10.1038/s41586-020-2785-8.

Jessica Tang, Eleanor Fewings, Darwin Chang ... Robert L Judson-Torres, Boris C Bastian, A Hunter Shain

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Cancer Biology, GenomicsNicholas LiaoFebruary 9, 20212020-10 (Oct)
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum
Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum

Neuron. 2021 Jan 20;109(2):299-313.e9. doi: 10.1016/j.neuron.2020.10.005.

Marijn Kuijpers, Gaga Kochlamazashvili, Alexander Stumpf ... Tanja Maritzen, Dietmar Schmitz, Volker Haucke

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Metabolism, Neuroscience, Cell & Developmental BioNicholas LiaoFebruary 2, 20212021-01 (Jan)
Actin chromobody imaging reveals sub-organellar actin dynamics
Actin chromobody imaging reveals sub-organellar actin dynamics

Nat Methods. 2020 Sep;17(9):917-921. doi: 10.1038/s41592-020-0926-5.

Cara R Schiavon, Tong Zhang, Bing Zhao ... Gerald S Shadel, Robert Grosse, Uri Manor

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Cell & Developmental BioNicholas LiaoJanuary 28, 20212020-09 (Sep)
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