Opposing Influence of Top-down and Bottom-up Input on Excitatory Layer 2/3 Neurons in Mouse Primary Visual Cortex

Neuron. 2020 Dec 23;108(6):1194-1206.e5. doi: 10.1016/j.neuron.2020.09.024.

Rebecca Jordan, Georg B Keller

NeuroscienceNicholas LiaoJanuary 26, 20212020-12 (Dec)

Structure of the shutdown state of myosin-2

Nature. 2020 Dec;588(7838):515-520. doi: 10.1038/s41586-020-2990-5.

Charlotte A Scarff, Glenn Carrington, David Casas-Mao ... Peter J Knight, Neil A Ranson, Michelle Peckham

Structural BiologyNicholas LiaoJanuary 21, 20212020-12 (Dec)

Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome

Neuron. 2020 Dec 9;108(5):887-904.e12. doi: 10.1016/j.neuron.2020.09.010.

Bruno Pinto, Giovanni Morelli, Mohit Rastogi ... Andrea Contestabile, Laura E Perlini, Laura Cancedda

Neuroscience, MedicineNicholas LiaoJanuary 19, 20212020-12 (Dec)

Posterior amygdala regulates sexual and aggressive behaviors in male mice

Nat Neurosci. 2020 Sep;23(9):1111-1124. doi: 10.1038/s41593-020-0675-x.

Takashi Yamaguchi, Dongyu Wei, Soomin C Song, Byungkook Lim, Nicolas X Tritsch, Dayu Lin

NeuroscienceNicholas LiaoJanuary 14, 20212020-09 (Sep)

The endogenous neuronal complement inhibitor SRPX2 protects against complement-mediated synapse elimination during development

Nat Neurosci. 2020 Sep;23(9):1067-1078. doi: 10.1038/s41593-020-0672-0.

Qifei Cong, Breeanne M Soteros, Mackenna Wollet, Jun Hee Kim, Gek-Ming Sia

NeuroscienceNicholas LiaoJanuary 11, 20212020-09 (Sep)

Structure of the class D GPCR Ste2 dimer coupled to two G proteins

Nature. 2020 Dec 2. doi: 10.1038/s41586-020-2994-1.

Vaithish Velazhahan, Ning Ma, Gáspár Pándy-Szekeres ... David E Gloriam, Nagarajan Vaidehi, Christopher G Tate

Structural BiologyNicholas LiaoJanuary 7, 20212020-12 (Dec)

Gut-resident CX3CR1 hi macrophages induce tertiary lymphoid structures and IgA response in situ

Sci Immunol. 2020 Apr 10;5(46):eaax0062. doi: 10.1126/sciimmunol.aax0062.

Balázs Koscsó, Sravya Kurapati, Richard R Rodrigues ... Natalia Shulzhenko, Andrey Morgun, Milena Bogunovic

Immunology & MicrobiologyNicholas LiaoJanuary 5, 20212020-04 (Apr)

A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate

Nature. 2020 Dec 1. doi: 10.1038/s41586-020-3035-9.

Lorena Sanchez-Felipe, Thomas Vercruysse, Sapna Sharma ... Johan Neyts, Hendrik Jan Thibaut, Kai Dallmeier

COVID-19, Medicine, Immunology & MicrobiologyNicholas LiaoJanuary 4, 20212020-12 (Dec)

The neuropeptide Pth2 dynamically senses others via mechanosensation

Nature. 2020 Dec;588(7839):653-657. doi: 10.1038/s41586-020-2988-z.

Lukas Anneser, Ivan C Alcantara, Anja Gemmer, Kristina Mirkes, Soojin Ryu, Erin M Schuman

NeuroscienceNicholas LiaoDecember 30, 20202020-12 (Dec)

IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B cells

Nature. 2020 Dec;588(7838):491-497. doi: 10.1038/s41586-020-2884-6.

Jaewoong Lee, Mark E Robinson, Ning Ma ... Michael S Diamond, Nagarajan Vaidehi, Markus Müschen

Biochemistry, Immunology & Microbiology, Cancer BiologyNicholas LiaoDecember 29, 20202020-12 (Dec)

COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice

Nature. 2020 Nov 9. doi: 10.1038/s41586-020-2943-z.

Jian Zheng, Lok-Yin Roy Wong, Kun Li ... David K Meyerholz, Paul B McCray Jr, Stanley Perlman

COVID-19, Immunology & Microbiology, MedicineNicholas LiaoDecember 28, 20202020-11 (Nov)

A yeast living ancestor reveals the origin of genomic introgressions

Nature. 2020 Nov;587(7834):420-425. doi: 10.1038/s41586-020-2889-1.

Melania D'Angiolo, Matteo De Chiara, Jia-Xing Yue ... Eric Gilson, Jonas Warringer, Gianni Liti

Genetics & Genome BiologyNicholas LiaoDecember 24, 20202020-11 (Nov)

Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

Cancer Cell. 2020 Oct 12;38(4):567-583.e11. doi: 10.1016/j.ccell.2020.08.015.

Linara Gabitova-Cornell, Aizhan Surumbayeva, Suraj Peri ... Erica A Golemis, Edna Cukierman, Igor Astsaturov

Cancer Biology, MetabolismNicholas LiaoDecember 22, 20202020-10 (Oct)

Availability of food determines the need for sleep in memory consolidation

Nature. 2020 Dec 2. doi: 10.1038/s41586-020-2997-y.

Nitin S Chouhan, Leslie C Griffith, Paula Haynes, Amita Sehgal

NeuroscienceNicholas LiaoDecember 21, 20202020-12 (Dec)

Optimization of AsCas12a for combinatorial genetic screens in human cells

Nat Biotechnol. 2020 Jul 13. doi: 10.1038/s41587-020-0600-6.

Peter C DeWeirdt, Kendall R Sanson, Annabel K Sangree ... Xuewen Pan, Alan Huang, John G Doench

Biotechnology, Genetics & Genome BiologyNicholas LiaoDecember 17, 20202020-07 (Jul)

High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity

Immunity. 2020 Oct 13;53(4):759-774.e9. doi: 10.1016/j.immuni.2020.07.018.

Sunkyung Kim, Prachi Bagadia, David A Anderson 3rd ... Arifumi Iwata, Theresa L Murphy, Kenneth M Murphy

Immunology & MicrobiologyNicholas LiaoDecember 16, 20202020-10 (Oct)

Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes

Nat Genet. 2020 Aug;52(8):800-810. doi: 10.1038/s41588-020-0673-7.

Alessia Gagliardi, Vanessa L Porter, Zusheng Zong ... Daniela S Gerhard, Andrew J Mungall, Marco A Marra

Cancer Biology, GenomicsNicholas LiaoDecember 14, 20202020-08 (Aug)

Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

Nat Immunol. 2020 Oct;21(10):1244-1255. doi: 10.1038/s41590-020-0744-z.

Natalie M Edner, Frank Heuts, Niclas Thomas ... Mark Peakman, Miranda Rosenthal, Lucy S K Walker

Immunology & Microbiology, MedicineNicholas LiaoDecember 10, 20202020-10 (Oct)