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Research Films RSS
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A PGE 2-MEF2A axis enables context-dependent control of inflammatory gene expression
A PGE 2-MEF2A axis enables context-dependent control of inflammatory gene expression

Immunity. 2021 Jun 9;S1074-7613(21)00222-3. doi: 10.1016/j.immuni.2021.05.016.

Francesco Cilenti, Giulia Barbiera, Nicoletta Caronni ... Matteo Iannacone, Marco Genua, Renato Ostuni

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Immunology & Microbiology, Genetics & Genome BiologyNicholas LiaoAugust 12, 20212021-06 (Jun)
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia

Nat Commun. 2020 Nov 26;11(1):5998. doi: 10.1038/s41467-020-19782-x.

Kyle Spinler, Jeevisha Bajaj, Takahiro Ito ... Pyong Woo Park, Jeffrey D Esko, Tannishtha Reya

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Cancer BiologyNicholas LiaoAugust 10, 20212020-11 (Nov)
Single-cell mutation analysis of clonal evolution in myeloid malignancies
Single-cell mutation analysis of clonal evolution in myeloid malignancies

Nature. 2020 Nov;587(7834):477-482. doi: 10.1038/s41586-020-2864-x.

Linde A Miles, Robert L Bowman, Tiffany R Merlinsky ... Sara E Meyer, Aaron D Viny, Ross L Levine

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Cancer BiologyNicholas LiaoAugust 5, 20212020-11 (Nov)
Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling
Protein identification by 3D OrbiSIMS to facilitate in situ imaging and depth profiling

Nat Commun. 2020 Nov 17;11(1):5832. doi: 10.1038/s41467-020-19445-x.

Anna M Kotowska, Gustavo F Trindade, Paula M Mendes ... Alexander G Shard, Morgan R Alexander, David J Scurr

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Biochemistry, BiotechnologyNicholas LiaoAugust 3, 20212020-11 (Nov)
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

Immunity. 2021 Jun 8;54(6):1245-1256.e5. doi: 10.1016/j.immuni.2021.04.023.

Yi-Gen Pan, Benjamas Aiamkitsumrit, Laurent Bartolo ... Veronika I Zarnitsyna, Michael E Birnbaum, Laura F Su

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Immunology & MicrobiologyNicholas LiaoJuly 29, 20212021-06 (Jun)
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs
Deconstructing Stepwise Fate Conversion of Human Fibroblasts to Neurons by MicroRNAs

Cell Stem Cell. 2021 Jan 7;28(1):127-140.e9. doi: 10.1016/j.stem.2020.08.015.

Kitra Cates, Matthew J McCoy, Ji-Sun Kwon ... Harrison W Gabel, Samantha A Morris, Andrew S Yoo

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Cell & Developmental BioNicholas LiaoJuly 27, 20212021-01 (Jan)
Reducing effects of particle adsorption to the air-water interface in cryo-EM
Reducing effects of particle adsorption to the air-water interface in cryo-EM

Nat Methods. 2018 Oct;15(10):793-795. doi: 10.1038/s41592-018-0139-3.

Alex J Noble, Hui Wei, Venkata P Dandey ... Yong Zi Tan, Clinton S Potter, Bridget Carragher

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Structural BiologyNicholas LiaoJuly 22, 20212018-09 (Sep)
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus

Nat Commun. 2020 Nov 30;11(1):6088. doi: 10.1038/s41467-020-19937-w.

Xin Zhou, Yanghao Zhong, Olivia Molinar-Inglis ... JoAnn Trejo, Alexandra C Newton, Jin Zhang

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Biochemistry, Cell & Developmental BioNicholas LiaoJuly 20, 20212020-11 (Nov)
Condensation of Rubisco into a proto-pyrenoid in higher plant chloroplasts
Condensation of Rubisco into a proto-pyrenoid in higher plant chloroplasts

Nat Commun. 2020 Dec 9;11(1):6303. doi: 10.1038/s41467-020-20132-0.

Nicky Atkinson, Yuwei Mao, Kher Xing Chan, Alistair J McCormick

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Plant ScienceNicholas LiaoJuly 15, 20212020-12 (Dec)
Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles
Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

Nat Commun. 2020 Nov 6;11(1):5637. doi: 10.1038/s41467-020-19463-9.

Kerry L Hilligan, Shiau-Choot Tang, Evelyn J Hyde ... Alan Sher, Andrew S MacDonald, Franca Ronchese

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Immunology & MicrobiologyNicholas LiaoJuly 13, 20212020-11 (Nov)
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells

Nat Cell Biol. 2021 Feb;23(2):160-171. doi: 10.1038/s41556-020-00624-3.

Priyanka Verma, Yeqiao Zhou, Zhendong Cao ... Robert B Faryabi, Junwei Shi, Roger A Greenberg

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Cancer BiologyNicholas LiaoJuly 1, 20212021-02 (Feb)
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters
STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Nat Commun. 2020 Nov 17;11(1):5838. doi: 10.1038/s41467-020-19684-y.

Robbert Boudewijns, Hendrik Jan Thibaut, Suzanne J F Kaptein ... Zhongde Wang, Johan Neyts, Kai Dallmeier

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COVID-19, MicrobiologyNicholas LiaoJune 29, 20212020-11 (Nov)
Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production
Rate of Progression through a Continuum of Transit-Amplifying Progenitor Cell States Regulates Blood Cell Production

Dev Cell. 2019 Apr 8;49(1):118-129.e7. doi: 10.1016/j.devcel.2019.01.026.

Hojun Li, Anirudh Natarajan, Jideofor Ezike ... Clement Ma, Styliani Markoulaki, Harvey F Lodish

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Cell & Developmental BioNicholas LiaoJune 24, 20212019-04 (Apr)
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice
Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice

Sci Transl Med. 2020 Aug 19;12(557):eaay8798. doi: 10.1126/scitranslmed.aay8798.

Sarah Alsamman, Stephanie A Christenson, Amy Yu ... Alan C Mullen, Dean Sheppard, Jennifer Y Chen

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Medicine, MetabolismNicholas LiaoJune 22, 20212020-08 (Aug)
Modelling transmission and control of the COVID-19 pandemic in Australia
Modelling transmission and control of the COVID-19 pandemic in Australia

Nat Commun. 2020 Nov 11;11(1):5710. doi: 10.1038/s41467-020-19393-6.

Sheryl L Chang, Nathan Harding, Cameron Zachreson, Oliver M Cliff, Mikhail Prokopenko

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COVID-19Nicholas LiaoJune 17, 20212020-11 (Nov)
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity
A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity

Nat Commun. 2020 Dec 15;11(1):6389. doi: 10.1038/s41467-020-19929-w.

David Wylensek, Thomas C A Hitch, Thomas Riedel ... Tobias A M Gulder, Jörg Overmann, Thomas Clavel

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Metabolism, MicrobiologyNicholas LiaoJune 15, 20212020-12 (Dec)
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake

Cell Metab. 2020 Aug 4;32(2):273-286.e6. doi: 10.1016/j.cmet.2020.06.008.

Sharon O Jensen-Cody, Kyle H Flippo, Kristin E Claflin ... Deniz Atasoy, Matthew P Gillum, Matthew J Potthoff

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Metabolism, NeuroscienceNicholas LiaoJune 10, 20212020-08 (Aug)
A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding
A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding

Nat Commun. 2020 Dec 4;11(1):6218. doi: 10.1038/s41467-020-19980-7.

B Sofia Beas, Xinglong Gu, Yan Leng ... Alexxai V Kravitz, Mark A Hoon, Mario A Penzo

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Metabolism, NeuroscienceNicholas LiaoJune 8, 20212020-12 (Dec)
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