A lysine-cysteine redox switch with an NOS bridge regulates enzyme function

Nature. 2021 May;593(7859):460-464. doi: 10.1038/s41586-021-03513-3.

Marie Wensien, Fabian Rabe von Pappenheim, Lisa-Marie Funk ... Ricardo A Mata, Viktor Sautner, Kai Tittmann

BiochemistryNicholas LiaoJanuary 6, 20222021-05 (May)

Tracing the origin of hair follicle stem cells

Nature. 2021 Jun;594(7864):547-552. doi: 10.1038/s41586-021-03638-5.

Ritsuko Morita, Noriko Sanzen, Hiroko Sasaki ... Yasuhide Furuta, Itoshi Nikaido, Hironobu Fujiwara

Cell & Developmental BioNicholas LiaoJanuary 4, 20222021-06 (Jun)

Self-similar mesocrystals form via interface-driven nucleation and assembly

Nature. 2021 Feb;590(7846):416-422. doi: 10.1038/s41586-021-03300-0.

Guomin Zhu, Maria L Sushko, John S Loring ... Xiaopeng Huang, Kevin M Rosso, James J De Yoreo

Physical SciencesNicholas LiaoDecember 30, 20212021-02 (Feb)

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Cell. 2021 Jun 24;184(13):3502-3518.e33. doi: 10.1016/j.cell.2021.04.037.

Olivia Sveidahl Johansen, Tao Ma, Jakob Bondo Hansen ... Camilla Scheele, Susanne Mandrup, Zachary Gerhart-Hines

Metabolism, BiochemistryNicholas LiaoDecember 28, 20212021-06 (Jun)

Microglia use TAM receptors to detect and engulf amyloid β plaques

Nat Immunol. 2021 May;22(5):586-594. doi: 10.1038/s41590-021-00913-5.

Youtong Huang, Kaisa E Happonen, Patrick G Burrola ... Ling Huang, Axel Nimmerjahn, Greg Lemke

NeuroscienceNicholas LiaoDecember 23, 20212021-05 (May)

Two cGAS-like receptors induce antiviral immunity in Drosophila

Nature. 2021 Sep;597(7874):114-118. doi: 10.1038/s41586-021-03800-z.

Andreas Holleufer, Kasper Grønbjerg Winther, Hans Henrik Gad ... Hua Cai, Jean-Luc Imler, Rune Hartmann

Immunology & Microbiology, Cell & Developmental BioNicholas LiaoDecember 21, 20212021-09 (Sep)

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis

Cell. 2021 Aug 19;184(17):4579-4592.e24. doi: 10.1016/j.cell.2021.06.033.

Barbara Bosch, Michael A DeJesus, Nicholas C Poulton ... Brian T Chait, Dirk Schnappinger, Jeremy M Rock

MicrobiologyNicholas LiaoDecember 16, 20212021-08 (Aug)

Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

Cell. 2021 Jul 22;184(15):3998-4015.e19. doi: 10.1016/j.cell.2021.05.027.

Francesco Marangoni, Ademi Zhakyp, Michela Corsini ... Mauro Di Pilato, Shivashankar Othy, Thorsten R Mempel

Immunology & Microbiology, Cancer BiologyNicholas LiaoDecember 15, 20212021-07 (Jul)

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

Cell. 2021 Jul 22;184(15):4032-4047.e31. doi: 10.1016/j.cell.2021.05.038.

Sydney X Lu, Emma De Neef, James D Thomas ... Luis A Diaz Jr, Omar Abdel-Wahab, Robert K Bradley

Cancer Biology, Immunology & MicrobiologyNicholas LiaoDecember 14, 20212021-07 (Jul)

A condensate-hardening drug blocks RSV replication in vivo

Nature. 2021 Jul;595(7868):596-599. doi: 10.1038/s41586-021-03703-z.

Jennifer Risso-Ballester, Marie Galloux, Jingjing Cao ... Jean-François Eléouët, Marie-Anne Rameix-Welti, Ralf Altmeyer

Medicine, Cell & Developmental Bio, BiochemistryNicholas LiaoDecember 9, 20212021-07 (Jul)

Dietary fructose improves intestinal cell survival and nutrient absorption

Nature. 2021 Sep;597(7875):263-267. doi: 10.1038/s41586-021-03827-2.

Samuel R Taylor, Shakti Ramsamooj, Roger J Liang ... Lewis C Cantley, Kyu Y Rhee, Marcus D Goncalves

Metabolism, Cancer Biology, BiochemistryNicholas LiaoDecember 7, 20212021-09 (Sep)

Supply chain diversity buffers cities against food shocks

Nature. 2021 Jul;595(7866):250-254. doi: 10.1038/s41586-021-03621-0.

Michael Gomez, Alfonso Mejia, Benjamin L Ruddell, Richard R Rushforth

ClimateNicholas LiaoDecember 3, 20212021-07 (Jul)

Small RNAs are modified with N-glycans and displayed on the surface of living cells

Cell. 2021 Jun 10;184(12):3109-3124.e22. doi: 10.1016/j.cell.2021.04.023.

Ryan A Flynn, Kayvon Pedram, Stacy A Malaker ... Peter W Villalta, Jan E Carette, Carolyn R Bertozzi

Biochemistry, Cell & Developmental BioNicholas LiaoDecember 1, 20212021-06 (Jun)

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion

Science. 2021 Jul 30;373(6554):eabd2893. doi: 10.1126/science.abd2893.

Ruth Choa, Junichiro Tohyama, Shogo Wada ... Mingyao Li, Zoltan Arany, Taku Kambayashi

Immunology & Microbiology, MetabolismNicholas LiaoNovember 29, 20212021-07 (Jul)

Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling

Nature. 2021 Sep;597(7875):245-249. doi: 10.1038/s41586-021-03845-0.

Stephen X Zhang, Andrew Lutas, Shang Yang ... Georg Nagel, Shiqiang Gao, Mark L Andermann

NeuroscienceNicholas LiaoNovember 18, 20212021-09 (Sep)

Developmental and temporal characteristics of clonal sperm mosaicism

Cell. 2021 Sep 2;184(18):4772-4783.e15. doi: 10.1016/j.cell.2021.07.024.

Xiaoxu Yang, Martin W Breuss, Xin Xu ... Yan Ding, Jonathan Sebat, Joseph G Gleeson

GenomicsNicholas LiaoNovember 16, 20212021-09 (Sep)

Quantum-enhanced nonlinear microscopy

Nature. 2021 Jun;594(7862):201-206. doi: 10.1038/s41586-021-03528-w.

Catxere A Casacio, Lars S Madsen, Alex Terrasson ... Boris Hage, Michael A Taylor, Warwick P Bowen

BiotechnologyNicholas LiaoNovember 11, 20212021-06 (Jun)

Expansible residence decentralizes immune homeostasis

Nature. 2021 Apr;592(7854):457-462. doi: 10.1038/s41586-021-03351-3.

Sathi Wijeyesinghe, Lalit K Beura, Mark J Pierson ... Pamela C Rosato, Vaiva Vezys, David Masopust

Immunology & MicrobiologyNicholas LiaoNovember 9, 20212021-04 (Apr)