Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

Cancer Cell. 2021 Dec 13;39(12):1578-1593.e8. doi: 10.1016/j.ccell.2021.09.010.

Yuanyuan Zhang, Hongyan Chen, Hongnan Mo ... Fei Ma, Zemin Zhang, Zhihua Liu

Cancer BiologyNicholas LiaoMay 19, 20222021-12 (Dec)

Brain glycogen serves as a critical glucosamine cache required for protein glycosylation

Cell Metab. 2021 Jul 6;33(7):1404-1417.e9. doi: 10.1016/j.cmet.2021.05.003.

Ramon C Sun, Lyndsay E A Young, Ronald C Bruntz ... Thomas D Hurley, Richard R Drake, Matthew S Gentry

Biochemistry, Neuroscience, MetabolismNicholas LiaoMay 17, 20222021-07 (Jul)

SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network

Nat Methods. 2021 Nov;18(11):1342-1351. doi: 10.1038/s41592-021-01255-8.

Jian Hu, Xiangjie Li, Kyle Coleman ... Edward B Lee, Russell T Shinohara, Mingyao Li

Genetics & Genome Biology, GenomicsNicholas LiaoMay 12, 20222021-11 (Nov)

A glial ClC Cl - channel mediates nose touch responses in C. elegans

Neuron. 2022 Feb 2;110(3):470-485.e7. doi: 10.1016/j.neuron.2021.11.010.

Jesus Fernandez-Abascal, Christina K Johnson, Bianca Graziano, Lei Wang, Nicole Encalada, Laura Bianchi

NeuroscienceNicholas LiaoMay 10, 20222022-02 (Feb)

Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors

Nat Methods. 2021 Jun;18(6):643-651. doi: 10.1038/s41592-021-01172-w.

Zhixin Lei, Haowei Meng, Zhicong Lv ... Kailin Yin, Yongchang Yan, Chengqi Yi

Genetics & Genome Biology, BiotechnologyNicholas LiaoMay 5, 20222021-06 (Jun)

Distinct nuclear compartment-associated genome architecture in the developing mammalian brain

Nat Neurosci. 2021 Sep;24(9):1235-1242. doi: 10.1038/s41593-021-00879-5.

Sajad Hamid Ahanger, Ryan N Delgado, Eugene Gil ... Tomasz J Nowakowski, Alex A Pollen, Daniel A Lim

Genetics & Genome Biology, NeuroscienceNicholas LiaoMay 3, 20222021-09 (Sep)

Curated variation benchmarks for challenging medically relevant autosomal genes

Nat Biotechnol. 2022 Feb 7. doi: 10.1038/s41587-021-01158-1.

Justin Wagner, Nathan D Olson, Lindsay Harris ... Chen-Shan Chin, Justin M Zook, Fritz J Sedlazeck

Biotechnology, Genetics & Genome Biology, MedicineNicholas LiaoApril 28, 20222022-02 (Feb)

Orphan CpG islands amplify poised enhancer regulatory activity and determine target gene responsiveness

Nat Genet. 2021 Jul;53(7):1036-1049. doi: 10.1038/s41588-021-00888-x.

Tomas Pachano, Víctor Sánchez-Gaya, Thais Ealo ... Wilfred F J van IJcken, David Landeira, Alvaro Rada-Iglesias

Genetics & Genome BiologyNicholas LiaoApril 26, 20222021-07 (Jul)

Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

Cell Metab. 2021 Sep 7;33(9):1836-1852.e11. doi: 10.1016/j.cmet.2021.07.010.

Zewen Jiang, Meng Zhao, Laetitia Voilquin ... Christopher D Gardner, Bruce M Spiegelman, Katrin J Svensson

MetabolismNicholas LiaoApril 14, 20222021-09 (Sep)

Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation

Nat Neurosci. 2021 Jul;24(7):941-953. doi: 10.1038/s41593-021-00858-w.

Dan Liang, Angela L Elwell, Nil Aygün ... Luis de la Torre-Ubieta, Daniel H Geschwind, Jason L Stein

Genetics & Genome Biology, NeuroscienceNicholas LiaoApril 12, 20222021-07 (Jul)

NeuroPAL: A Multicolor Atlas for Whole-Brain Neuronal Identification in C. elegans

Cell. 2021 Jan 7;184(1):272-288.e11. doi: 10.1016/j.cell.2020.12.012.

Eviatar Yemini, Albert Lin, Amin Nejatbakhsh ... Liam Paninski, Vivek Venkatachalam, Oliver Hobert

PI Seminars, Neuroscience, Cell & Developmental BioNicholas LiaoMarch 31, 20222021-01 (Jan)

Rescue of α-synuclein aggregation in Parkinson's patient neurons by synergistic enhancement of ER proteostasis and protein trafficking

Neuron. 2022 Feb 2;110(3):436-451.e11. doi: 10.1016/j.neuron.2021.10.032.

Iva Stojkovska, Willayat Y Wani, Friederike Zunke ... Karan Sharma, Laetitia Francelle, Joseph R Mazzulli

Neuroscience, Cell & Developmental BioNicholas LiaoMarch 29, 20222022-02 (Feb)

Spatial tissue profiling by imaging-free molecular tomography

Nat Biotechnol. 2021 Aug;39(8):968-977. doi: 10.1038/s41587-021-00879-7.

Halima Hannah Schede, Christian G Schneider, Johanna Stergiadou ... Maria Antonietta Tosches, Simone Codeluppi, Gioele La Manno

Biotechnology, Genomics, NeuroscienceNicholas LiaoMarch 24, 20222021-08 (Aug)

Synchronized cluster firing, a distinct form of sensory neuron activation, drives spontaneous pain

Neuron. 2022 Jan 19;110(2):209-220.e6. doi: 10.1016/j.neuron.2021.10.019.

Qin Zheng, Wenrui Xie, Debora D Lückemeyer ... Judith A Strong, Jun-Ming Zhang, Xinzhong Dong

NeuroscienceNicholas LiaoMarch 22, 20222022-01 (Jan)

Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

Nat Neurosci. 2021 Aug;24(8):1089-1099. doi: 10.1038/s41593-021-00864-y.

Roy Maimon, Carlos Chillon-Marinas, Cedric E Snethlage ... Thomas S Hnasko, Alysson R Muotri, Don W Cleveland

NeuroscienceNicholas LiaoMarch 17, 20222021-08 (Aug)

Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels: a double-blind, randomized controlled phase 3 trial

Nat Med. 2021 Oct;27(10):1752-1760. doi: 10.1038/s41591-021-01499-z.

Evdoxia Kyriazopoulou, Garyfallia Poulakou, Haralampos Milionis ... Periklis Panagopoulos, George N Dalekos, Evangelos J Giamarellos-Bourboulis

COVID-19, MedicineNicholas LiaoMarch 15, 20222021-10 (Oct)

Shared heritability of human face and brain shape

Nat Genet. 2021 Jun;53(6):830-839. doi: 10.1038/s41588-021-00827-w.

Sahin Naqvi, Yoeri Sleyp, Hanne Hoskens ... Hilde Peeters, Joanna Wysocka, Peter Claes

Genetics & Genome Biology, NeuroscienceNicholas LiaoMarch 10, 20222021-06 (Jun)

Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer

Cell Metab. 2021 Mar 2;33(3):499-512.e6. doi: 10.1016/j.cmet.2021.01.018.

Olivia A Maguire, Sarah E Ackerman, Sarah K Szwed ... Raghavendra G Mirmira, Lawrence Kazak, Paul Cohen

Cancer Biology, MetabolismNicholas LiaoMarch 8, 20222021-03 (Mar)