Dynamic regulation of B cell complement signaling is integral to germinal center responses

Nat Immunol. 2021 Jun;22(6):757-768. doi: 10.1038/s41590-021-00926-0.

Arun Cumpelik, David Heja, Yuan Hu ... Sergio A Lira, David Dominguez-Sola, Peter S Heeger

Immunology & MicrobiologyNicholas LiaoMarch 3, 20222021-06 (Jun)

Translation of GGC repeat expansions into a toxic polyglycine protein in NIID defines a novel class of human genetic disorders: The polyG diseases

Neuron. 2021 Jun 2;109(11):1825-1835.e5. doi: 10.1016/j.neuron.2021.03.038.

Manon Boivin, Jianwen Deng, Véronique Pfister ... Jun Sone, Zhaoxia Wang, Nicolas Charlet-Berguerand

Medicine, Neuroscience, Genetics & Genome BiologyNicholas LiaoMarch 1, 20222021-06 (Jun)

CLUSTER guide RNAs enable precise and efficient RNA editing with endogenous ADAR enzymes in vivo

Nat Biotechnol. 2022 Jan 3. doi: 10.1038/s41587-021-01105-0.

Philipp Reautschnig, Nicolai Wahn, Jacqueline Wettengel ... Lars Zender, Jin Billy Li, Thorsten Stafforst

Biotechnology, Biochemistry, Genetics & Genome BiologyNicholas LiaoFebruary 24, 20222022-01 (Jan)

Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

Cell Metab. 2021 Nov 2;33(11):2247-2259.e6. doi: 10.1016/j.cmet.2021.10.008.

Giulia Salvadori, Federica Zanardi, Fabio Iannelli, Riccardo Lobefaro, Claudio Vernieri, Valter D Longo

Cancer Biology, Metabolism, BiochemistryNicholas LiaoFebruary 22, 20222021-11 (Nov)

Standardized preservation, extraction and quantification techniques for detection of fecal SARS-CoV-2 RNA

Nat Commun. 2021 Oct 1;12(1):5753. doi: 10.1038/s41467-021-25576-6.

Aravind Natarajan, Alvin Han, Soumaya Zlitni ... Benjamin A Pinsky, Alexandria Boehm, Ami S Bhatt

COVID-19, MedicineNicholas LiaoFebruary 17, 20222021-10 (Oct)

Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components

Neuron. 2021 May 19;109(10):1675-1691.e9. doi: 10.1016/j.neuron.2021.03.026.

Evan Lester, Felicia K Ooi, Nadine Bakkar ... George A Carlson, Stanley B Prusiner, Roy Parker

Neuroscience, Biochemistry, MedicineNicholas LiaoFebruary 15, 20222021-05 (May)

Divergent brainstem opioidergic pathways that coordinate breathing with pain and emotions

Neuron. 2021 Dec 15;S0896-6273(21)00990-9. doi: 10.1016/j.neuron.2021.11.029.

Shijia Liu, Mao Ye, Gerald M Pao ... Sukjae J Kang, Dong-Il Kim, Sung Han

NeuroscienceNicholas LiaoFebruary 10, 20222021-12 (Dec)

Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD + to alleviate mitochondrial disease

Cell Metab. 2021 Oct 5;33(10):1974-1987.e9. doi: 10.1016/j.cmet.2021.06.013.

Shanshan Liu, Song Fu, Guodong Wang ... Mengqiu Dong, Qinghua Liu, Hui Jiang

Cell & Developmental Bio, Biochemistry, MetabolismNicholas LiaoFebruary 8, 20222021-10 (Oct)

High-throughput and high-dimensional single-cell analysis of antigen-specific CD8 + T cells

Nat Immunol. 2021 Dec;22(12):1590-1598. doi: 10.1038/s41590-021-01073-2.

Ke-Yue Ma, Alexandra A Schonnesen, Chenfeng He ... Robert Balderas, Mrinalini Kulkarni-Date, Ning Jiang

Biotechnology, Immunology & MicrobiologyNicholas LiaoFebruary 4, 20222021-12 (Dec)

Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Cell Metab. 2021 Aug 3;33(8):1685-1700.e9. doi: 10.1016/j.cmet.2021.06.005.

Anne Loft, Ana Jimena Alfaro, Søren Fisker Schmidt ... Mauricio Berriel Diaz, Blagoy Blagoev, Stephan Herzig

Metabolism, Biochemistry, MedicineNicholas LiaoFebruary 3, 20222021-08 (Aug)

Auto-aggressive CXCR6 + CD8 T cells cause liver immune pathology in NASH

Nature. 2021 Apr;592(7854):444-449. doi: 10.1038/s41586-021-03233-8.

Michael Dudek, Dominik Pfister, Sainitin Donakonda ... Jan P Böttcher, Mathias Heikenwälder, Percy A Knolle

Immunology & Microbiology, MetabolismNicholas LiaoFebruary 1, 20222021-04 (Apr)

Circadian clocks guide dendritic cells into skin lymphatics

Nat Immunol. 2021 Nov;22(11):1375-1381. doi: 10.1038/s41590-021-01040-x.

Stephan J Holtkamp, Louise M Ince, Coline Barnoud ... Henrik Oster, Jörg Renkawitz, Christoph Scheiermann

Immunology & MicrobiologyNicholas LiaoJanuary 28, 20222021-11 (Nov)

Human oral mucosa cell atlas reveals a stromal-neutrophil axis regulating tissue immunity

Cell. 2021 Jul 22;184(15):4090-4104.e15. doi: 10.1016/j.cell.2021.05.013.

Drake Winslow Williams, Teresa Greenwell-Wild, Laurie Brenchley ... Maria Morasso, Muzlifah Haniffa, Niki Maria Moutsopoulos

Immunology & Microbiology, Genomics, MedicineNicholas LiaoJanuary 27, 20222021-07 (Jul)

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

Nature. 2021 Jul;595(7865):101-106. doi: 10.1038/s41586-021-03626-9.

Karen O Dixon, Marcin Tabaka, Markus A Schramm ... Orit Rozenblatt-Rosen, Aviv Regev, Vijay K Kuchroo

Immunology & Microbiology, Cancer BiologyNicholas LiaoJanuary 25, 20222021-07 (Jul)

Techniques for Collaborative Development of AI Models in the Age of COVID

Nat Med. 2021 Oct;27(10):1735-1743. doi: 10.1038/s41591-021-01506-3.

Ittai Dayan, Holger R Roth, Aoxiao Zhong ... Fiona J Gilbert, Mona G Flores, Quanzheng Li

Seminars, COVID-19, MedicineNicholas LiaoJanuary 20, 20222021-10 (Oct)

Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote T H 2 and inhibit T H 17 cell polarization

Nat Immunol. 2021 Dec;22(12):1538-1550. doi: 10.1038/s41590-021-01067-0.

Johannes U Mayer, Kerry L Hilligan, Jodie S Chandler ... Matthew R Hepworth, Olivier Lamiable, Franca Ronchese

Cell & Developmental Bio, Immunology & MicrobiologyNicholas LiaoJanuary 18, 20222021-12 (Dec)

Widespread deoxygenation of temperate lakes

Nature. 2021 Jun;594(7861):66-70. doi: 10.1038/s41586-021-03550-y.

Stephen F Jane, Gretchen J A Hansen, Benjamin M Kraemer ... Gesa A Weyhenmeyer, Kiyoko Yokota, Kevin C Rose

ClimateNicholas LiaoJanuary 13, 20222021-06 (Jun)

Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

Cell. 2021 Jul 22;184(15):4016-4031.e22. doi: 10.1016/j.cell.2021.05.021.

Evangelos Giampazolias, Oliver Schulz, Kok Haw Jonathan Lim ... Sunita Varsani-Brown, Ian Rosewell, Caetano Reis E Sousa

Cancer BiologyNicholas LiaoJanuary 11, 20222021-07 (Jul)