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Posts in Structural Biology

Bending forces and nucleotide state jointly regulate F-actin structure

Bending forces and nucleotide state jointly regulate F-actin structure

Nature. 2022 Nov;611(7935):380-386. doi: 10.1038/s41586-022-05366-w.

Matthew J Reynolds, Carla Hachicho, Ayala G Carl, Rui Gong, Gregory M Alushin

Biochemistry, Structural BiologyNicholas LiaoJanuary 6, 20232022-11 (Nov)

Reducing effects of particle adsorption to the air-water interface in cryo-EM

Reducing effects of particle adsorption to the air-water interface in cryo-EM

Nat Methods. 2018 Oct;15(10):793-795. doi: 10.1038/s41592-018-0139-3.

Alex J Noble, Hui Wei, Venkata P Dandey ... Yong Zi Tan, Clinton S Potter, Bridget Carragher

Structural BiologyNicholas LiaoJuly 22, 20212018-09 (Sep)

Structure of the shutdown state of myosin-2

Structure of the shutdown state of myosin-2

Nature. 2020 Dec;588(7838):515-520. doi: 10.1038/s41586-020-2990-5.

Charlotte A Scarff, Glenn Carrington, David Casas-Mao ... Peter J Knight, Neil A Ranson, Michelle Peckham

Structural BiologyNicholas LiaoJanuary 21, 20212020-12 (Dec)

Structure of the class D GPCR Ste2 dimer coupled to two G proteins

Structure of the class D GPCR Ste2 dimer coupled to two G proteins

Nature. 2020 Dec 2. doi: 10.1038/s41586-020-2994-1.

Vaithish Velazhahan, Ning Ma, Gáspár Pándy-Szekeres ... David E Gloriam, Nagarajan Vaidehi, Christopher G Tate

Structural BiologyNicholas LiaoJanuary 7, 20212020-12 (Dec)

Structures of Neisseria Meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States

Structures of Neisseria Meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States

Mol Cell. 2019 Dec 19;76(6):938-952.e5.

Wei Sun, Jing Yang, Zhi Cheng … Jizhong Lou, Erik J Sontheimer, Yanli Wang

Structural BiologyNicholas LiaoJune 5, 20202019-12 (Dec)

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Nature. 2019 Apr;568(7752):415-419.

Lu M, Ma X, Castillo-Menendez LR, Blanchard SC, Sodroski JG, Mothes W.

Structural Biology, Immunology & MicrobiologyNicholas LiaoMay 1, 20202019-04 (Apr)

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

Cell. 2019 Mar 7;176(6):1490-1501.e12.

Worden EJ, Hoffmann NA, Hicks CW, Wolberger C.

Structural Biology, BiochemistryNicholas LiaoApril 13, 20202019-03 (Mar)

QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity.

QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25668-25676.

Qing R, Han Q, Skuhersky M, Chung H, Badr M, Schubert T, Zhang S.

Biochemistry, Structural BiologyDavid CantorMarch 27, 20202019-12 (Dec)

Structure and mechanism of mitochondrial proton-translocating transhydrogenase

Structure and mechanism of mitochondrial proton-translocating transhydrogenase

Kampjut D, Sazanov LA.

Nature. 2019 Sep;573(7773):291-295.

Structural Biology, BiochemistryVictoria FangNovember 21, 20192019-09 (Sep)

Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor

Cryo-EM Structure of Chikungunya Virus in Complex with the Mxra8 Receptor

Basore K, Kim AS, Nelson CA, Zhang R, Smith BK, Uranga C, Vang L, Cheng M, Gross ML, Smith J, Diamond MS, Fremont DH.

Cell. 2019 Jun 13;177(7):1725-1737.e16.

Structural Biology, Immunology & MicrobiologyVictoria FangNovember 15, 20192019-06 (Jun)