Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas

Cancer Cell. 2020 Apr 13;37(4):569-583.e5. doi: 10.1016/j.ccell.2020.03.011.

Scott Ryall, Michal Zapotocky, Kohei Fukuoka ... David W Ellison, Uri Tabori, Cynthia Hawkins

Cancer Biology, GenomicsNicholas LiaoAugust 10, 202004, 2020-04 (Apr)

The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors Through Inhibition of STING Signaling

Immunity. 2020 Apr 14;52(4):668-682.e7. doi: 10.1016/j.immuni.2020.03.004.

Eslam Mohamed, Rosa A Sierra, Jimena Trillo-Tinoco ... Juan R Cubillos-Ruiz, Jose R Conejo-Garcia, Paulo C Rodriguez

Cancer Biology, Metabolism, Immunology & MicrobiologyNicholas LiaoJuly 20, 20202020-04 (Apr)

Combination PD-1 and PD-L1 Blockade Promotes Durable Neoantigen-Specific T Cell-Mediated Immunity in Pancreatic Ductal Adenocarcinoma

Cell Rep. 2019 Aug 20;28(8):2140-2155.e6. doi: 10.1016/j.celrep.2019.07.059.

Adam L Burrack, Ellen J Spartz, Jackson F Raynor, Iris Wang, Margaret Olson, Ingunn M Stromnes

Cancer Biology, Immunology & MicrobiologyNicholas LiaoJune 27, 20202019-08 (Aug)

FBP1 Loss Disrupts Liver Metabolism and Promotes Tumorigenesis Through a Hepatic Stellate Cell Senescence Secretome

Nat Cell Biol. 2020 May 4.

Fuming Li, Peiwei Huangyang, Michelle Burrows … Brian Keith, Bo Li, M Celeste Simon

Cancer Biology, MetabolismNicholas LiaoJune 1, 20202020-05 (May)

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Nat Genet. 2020 Apr;52(4):408-417.

Lin KH, Rutter JC, Xie A…Crawford L, Puissant A, Wood KC.

Cancer BiologyNicholas LiaoMay 7, 20202020-04 (Apr)

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Cell Metab. 2020 Jan 7;31(1):174-188.e7.

Huangyang P, Li F, Lee P, Keith B, Yoon SS, Simon MC.

Cancer Biology, MetabolismNicholas LiaoMay 4, 20202020-01 (Jan)

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

Dev Cell. 2019 Sep 23;50(6):690-703.e6.

Towers CG, Fitzwalter BE, Regan D, Liu CW, Gustafson DL, Thorburn A.

Cancer Biology, Cell & Developmental BioNicholas LiaoApril 27, 20202019-09 (Sep)

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.

Nat Med. 2019 Dec;25(12):1938-1947.

Khan S, Zhang X, Lv D, Konopleva M, Zheng G, Zhou D.

Cancer BiologyNicholas LiaoApril 25, 20202019-12 (Dec)

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

Mol Cell. 2019 May 16;74(4):688-700.e3

Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE.

Genomics, Biochemistry, Cancer BiologyNicholas LiaoApril 11, 20202019-05 (May)

The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

Cancer Cell. 2019 Aug 12;36(2):139-155.e10

Su W, Han HH, Wang Y…Scher H, Ouerfelli O, Giancotti FG.

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Mol Cell. 2019 Apr 18;74(2):378-392.e5.

Baffi TR, Van AN, Zhao W, Mills GB, Newton AC.

Biochemistry, Cancer Biology, MedicineDavid CantorMarch 25, 20202019-04 (Apr)

Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.

Cell Stem Cell. 2018 Apr 5;22(4):501-513.e7.

Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC.

Adaptive mutability of colorectal cancers in response to targeted therapies.

Science. 2019 Dec 20;366(6472):1473-1480

Russo M, Crisafulli G, Sogari A, Reilly NM, Arena S…Lagomarsino MC, Di Nicolantonio F, Bardelli A.

Cancer Biology, MedicineVictoria FangMarch 3, 2020

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal

Liu M, O'Connor RS, Trefely S, Graham K, Snyder NW, Beatty GL.

Nat Immunol. 2019 Jan 21;20(3):265-275.

Cancer Biology, Immunology & Microbiology, MetabolismVictoria FangDecember 2, 20192019-01 (Jan)

Identifying Epistasis in Cancer Genomes: A Delicate Affair

van de Haar J, Canisius S, Yu MK, Voest EE, Wessels LFA, Ideker T.

Cell. 2019 May 30;177(6):1375-1383.

Cancer Biology, Medicine, Genetics & Genome BiologyVictoria FangNovember 18, 20192019-05 (May)

Metastatic-niche labelling reveals parenchymal cells with stem features

Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee JH, Malanchi I.

Nature. 2019 Aug;572(7771):603-608.

Cancer Biology, Cell & Developmental BioVictoria FangNovember 11, 20192019-08 (Aug)

LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors.

Egolf S#, Aubert Y#, Doepner M, Anderson A, Maldonado-Lopez A, Pacella G, Lee J, Ko EK, Zou J, Lan Y, Simpson CL, Ridky T, Capell BC.

#Contributed equally

Cell Rep. 2019 Aug 20;28(8):1981-1992.e7

Cancer Biology, Genetics & Genome BiologyVictoria FangOctober 29, 20192019-08 (Aug)

A multimodality test to guide the management of patients with a pancreatic cyst.

Springer S, Masica DL, Dal Molin M, Douville C, Thoburn CJ…Klein AP, Tomasetti C, Karchin R, Papadopoulos N, Kinzler KW, Vogelstein B, Wolfgang CL, Hruban RH, Lennon AM.

Sci Transl Med. 2019 Jul 17;11(501).

Medicine, Cancer BiologyVictoria FangOctober 8, 20192019-07 (Jul)