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Research Films RSS
Screen Shot 2019-08-28 at 10.03.25 PM.png
Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease
Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

Mol Cell. 2019 May 16;74(4):688-700.e3

Roake CM, Chen L, Chakravarthy AL, Ferrell JE Jr, Raffa GD, Artandi SE.

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Genomics, Biochemistry, Cancer BiologyNicholas LiaoApril 11, 20202019-05 (May)
Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants
Maternal IgA protects against the development of necrotizing enterocolitis in preterm infants

Nat Med. 2019 Jul;25(7):1110-1115.

Gopalakrishna KP, Macadangdang BR, Rogers MB, Good M, Morowitz MJ, Hand TW.

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Cell & Developmental Bio, Immunology & MicrobiologyNicholas LiaoApril 8, 20202019-07 (Jul)
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.
The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression.

Cancer Cell. 2019 Aug 12;36(2):139-155.e10

Su W, Han HH, Wang Y…Scher H, Ouerfelli O, Giancotti FG.

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Cancer Biology, Immunology & Microbiology, Genetics & Genome BiologyVictoria FangApril 4, 20202019-08 (Aug)
Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules.
Proximity RNA Labeling by APEX-Seq Reveals the Organization of Translation Initiation Complexes and Repressive RNA Granules.

Mol Cell. 2019 Aug 22;75(4):875-887.e5.

Padrón A, Iwasaki S, Ingolia NT.

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Biochemistry, Cell & Developmental Bio, GenomicsDavid CantorMarch 31, 20202019-08 (Aug)
QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity.
QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity.

Proc Natl Acad Sci U S A. 2019 Dec 17;116(51):25668-25676.

Qing R, Han Q, Skuhersky M, Chung H, Badr M, Schubert T, Zhang S.

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Biochemistry, Structural BiologyDavid CantorMarch 27, 20202019-12 (Dec)
Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.
Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Mol Cell. 2019 Apr 18;74(2):378-392.e5.

Baffi TR, Van AN, Zhao W, Mills GB, Newton AC.

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Biochemistry, Cancer Biology, MedicineDavid CantorMarch 25, 20202019-04 (Apr)
The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates
The extracellular DNA lattice of bacterial biofilms is structurally related to Holliday junction recombination intermediates

Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25068-25077.

Devaraj A, Buzzo JR, Mashburn-Warren L, Gloag ES, Novotny LA, Stoodley P, Bakaletz LO, Goodman SD.

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Biochemistry, Immunology & MicrobiologyVictoria FangMarch 24, 20202019-12 (Dec)
TREM2 function impedes tau seeding in neuritic plaques.
TREM2 function impedes tau seeding in neuritic plaques.

Nat Neurosci. 2019 Aug;22(8):1217-1222.

Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM.

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NeuroscienceVictoria FangMarch 20, 20202019-08 (Aug)
Actin protrusions push at apical junctions to maintain E-cadherin adhesion.
Actin protrusions push at apical junctions to maintain E-cadherin adhesion.

Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):432-438.

Li JXH, Tang VW, Brieher WM.

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Cell & Developmental BioVictoria FangMarch 11, 20202020-01 (Jan)
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.
Autologous iPSC-Based Vaccines Elicit Anti-tumor Responses In Vivo.

Cell Stem Cell. 2018 Apr 5;22(4):501-513.e7.

Kooreman NG, Kim Y, de Almeida PE, Termglinchan V, Diecke S, Shao NY, Wei TT, Yi H, Dey D, Nelakanti R, Brouwer TP, Paik DT, Sagiv-Barfi I, Han A, Quax PHA, Hamming JF, Levy R, Davis MM, Wu JC.

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Cell & Developmental Bio, Cancer Biology, Immunology & MicrobiologyVictoria FangMarch 10, 20202018-04 (Apr)
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG

Mol Cell. 2019 Oct 3;76(1):70-81.e9

Zhou KI, Shi H, Lyu R, Wylder AC, Matuszek Ż, Pan JN, He C, Parisien M, Pan T.

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Biochemistry, Cell & Developmental BioVictoria FangMarch 9, 20202019-10 (Oct)
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models.
Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models.

Nat Neurosci. 2019 Mar;22(3):413-420

Cruz Hernández JC#, Bracko O#, Kersbergen CJ, Muse V, Haft-Javaherian M…Nishimura N, Schaffer CB.

#Contributed equally

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NeuroscienceVictoria FangMarch 5, 20202019-03 (Mar)
Adaptive mutability of colorectal cancers in response to targeted therapies.
Adaptive mutability of colorectal cancers in response to targeted therapies.

Science. 2019 Dec 20;366(6472):1473-1480

Russo M, Crisafulli G, Sogari A, Reilly NM, Arena S…Lagomarsino MC, Di Nicolantonio F, Bardelli A.

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Cancer Biology, MedicineVictoria FangMarch 3, 2020
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions.

Science. 2020 Jan 31;367(6477):528-537

Cserép C#, Pósfai B#, Lénárt N, Fekete R, László ZI… Katona I, Liesz A, Tamás G, Dénes Á.

#Contributed equally

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Neuroscience, Cell & Developmental BioVictoria FangMarch 2, 20202020-01 (Jan)
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit
Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

Cell Stem Cell. 2020 Apr 2;26(4):558-568.e9. doi: 10.1016/j.stem.2020.01.018.

Christopher S Morrow, Tiaira J Porter, Nan Xu ... Helen J Heo, Elizabeth A N Thompson, Darcie L Moore

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Cell & Developmental Bio, NeuroscienceVictoria FangFebruary 27, 20202020-02 (Feb)
Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System
Atoh1 Directs Regeneration and Functional Recovery of the Mature Mouse Vestibular System

Cell Rep. 2019 Jul 9;28(2):312-324.e4

 Sayyid ZN, Wang T, Chen L, Jones SM, Cheng AG.

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Cell & Developmental Bio, Genetics & Genome BiologyVictoria FangFebruary 4, 20202019-07 (Jul)
Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women
Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women

Cell. 2019 Jun 27;178(1):190-201.e11. 

Martinez DR, Fong Y, Li SH, Yang F, Jennewein MF, Weiner JA, Harrell EA, Mangold JF, Goswami R, Seage GR 3rd, Alter G, Ackerman ME, Peng X, Fouda GG, Permar SR.

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Biochemistry, Immunology & Microbiology, MedicineVictoria FangJanuary 30, 20202019-06 (Jun)
Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.
Multispecific anti-HIV duoCAR-T cells display broad in vitro antiviral activity and potent in vivo elimination of HIV-infected cells in a humanized mouse model.

Sci Transl Med. 2019 Aug 7;11(504).  

Anthony-Gonda K#, Bardhi A#, Ray A, Flerin N, Li M… Dimitrov DS, Goldstein H, Dropulić B.

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Immunology & Microbiology, Medicine, BiochemistryVictoria FangJanuary 29, 20202019-08 (Aug)
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