Latest research films — JRNLclub, the online journal club

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Cell Metab. 2019 Sep 3;30(3):447-461.e5.

Nicholas DA, Proctor EA, Agrawal M…Kern PA, Lauffenburger DA, Nikolajczyk BS.

Metabolism, Medicine, Immunology & MicrobiologyNicholas LiaoMay 15, 20202019-09 (Sep)

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.

Nat Immunol. 2020 Jan;21(1):65-74.

Jain A, Irizarry-Caro RA, McDaniel MM, …, Chervonsky AV, Katz JD, Pasare C.

Immunology & MicrobiologyNicholas LiaoMay 14, 20202020-01 (Jan)

RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis.

RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis.

Dev Cell. 2020 Jan 27;52(2):152-166.e5.

Cavanaugh KE, Staddon MF, Munro E, Banerjee S, Gardel ML.

Cell & Developmental BioNicholas LiaoMay 13, 20202020-01 (Jan)

GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion.

GRASP55 and UPR Control Interleukin-1β Aggregation and Secretion.

Dev Cell. 2019 Apr 8;49(1):145-155.e4.

Chiritoiu M, Brouwers N, Turacchio G, Pirozzi M, Malhotra V.

Cell & Developmental BioNicholas LiaoMay 12, 20202019-04 (Apr)

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

Butyrophilin-2A1 Directly Binds Germline-Encoded Regions of the Vγ9Vδ2 TCR and Is Essential for Phosphoantigen Sensing

Immunity. 2020 Mar 17;52(3):487-498.e6.

Karunakaran MM, Willcox CR, Salim M, Mohammed F, Willcox BE, Herrmann T.

Immunology & MicrobiologyNicholas LiaoMay 10, 20202020- 03 (Mar)

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer.

Nat Genet. 2020 Apr;52(4):408-417.

Lin KH, Rutter JC, Xie A…Crawford L, Puissant A, Wood KC.

Cancer BiologyNicholas LiaoMay 7, 20202020-04 (Apr)

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

Suppression of Inflammasome Activation by IRF8 and IRF4 in cDCs Is Critical for T Cell Priming

Cell Rep. 2020 May 5;31(5):107604.

McDaniel MM, Kottyan LC, Singh H, Pasare C.

Immunology & MicrobiologyNicholas LiaoMay 5, 20202020-05 (May)

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.

Cell Metab. 2020 Jan 7;31(1):174-188.e7.

Huangyang P, Li F, Lee P, Keith B, Yoon SS, Simon MC.

Cancer Biology, MetabolismNicholas LiaoMay 4, 20202020-01 (Jan)

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Nature. 2019 Apr;568(7752):415-419.

Lu M, Ma X, Castillo-Menendez LR, Blanchard SC, Sodroski JG, Mothes W.

Structural Biology, Immunology & MicrobiologyNicholas LiaoMay 1, 20202019-04 (Apr)

LncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

LncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

Mol Cell. 2019 Aug 8;75(3):523-537.e10.

Schertzer MD, Braceros KCA, Starmer J, Dowen JM, Magnuson T, Calabrese JM.

Cell & Developmental Bio, Genetics & Genome BiologyNicholas LiaoApril 30, 20202019-08 (Aug)

Dynamic Podosome-Like Structures in Nascent Phagosomes Are Coordinated by Phosphoinositides.

Dynamic Podosome-Like Structures in Nascent Phagosomes Are Coordinated by Phosphoinositides.

Dev Cell. 2019 Aug 19;50(4):397-410.e3.

Ostrowski PP, Freeman SA, Fairn G, Grinstein S.

Cell & Developmental BioNicholas LiaoApril 29, 20202019-08 (Aug)

NLRP3 inflammasome activation drives tau pathology.

NLRP3 inflammasome activation drives tau pathology.

Nature. 2019 Nov;575(7784):669-673.

Ising C, Venegas C, Zhang S, Latz E, Buée L, Heneka MT.

Neuroscience, BiochemistryNicholas LiaoApril 28, 20202019-11 (Nov)

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition.

Dev Cell. 2019 Sep 23;50(6):690-703.e6.

Towers CG, Fitzwalter BE, Regan D, Liu CW, Gustafson DL, Thorburn A.

Cancer Biology, Cell & Developmental BioNicholas LiaoApril 27, 20202019-09 (Sep)

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.

A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.

Nat Med. 2019 Dec;25(12):1938-1947.

Khan S, Zhang X, Lv D, Konopleva M, Zheng G, Zhou D.

Cancer BiologyNicholas LiaoApril 25, 20202019-12 (Dec)

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring.

Cell Metab. 2019 Dec 3;30(6):1055-1074.e8.

Pucino V, Certo M, Bulusu V, Bombardieri M, Pitzalis C, Mauro C.

Immunology & Microbiology, MetabolismNicholas LiaoApril 24, 20202019-12 (Dec)

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

Nat Neurosci. 2019 Jun;22(6):1021-1035.

Van Hove H, Martens L, Scheyltjens I, Van Ginderachter JA, Saeys Y, Movahedi K.

NeuroscienceNicholas LiaoApril 17, 20202019-06 (Jun)

Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway

Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway

Nature. 2020 Mar;579(7799):427-432

Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M.

Biochemistry, Cell & Developmental BioVictoria FangApril 15, 20202020- 03 (Mar)

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L

Cell. 2019 Mar 7;176(6):1490-1501.e12.

Worden EJ, Hoffmann NA, Hicks CW, Wolberger C.

Structural Biology, BiochemistryNicholas LiaoApril 13, 20202019-03 (Mar)